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Improving oral absorption of samon calcitonin by trimyristin lipid nanoparticles

dc.contributor.authorMartins, S.
dc.contributor.authorSilva, Ana Catarina
dc.contributor.authorFerreira, D.C.
dc.contributor.authorSouto, Eliana B.
dc.date.accessioned2021-05-06T14:06:13Z
dc.date.available2021-05-06T14:06:13Z
dc.date.issued2008
dc.description.abstractSolid lipid nanoparticles (SLN) composed of trimyristin (solid lipid) and poloxamer 407 (surfactant) were prepared by a w/o/w emulsion technique for the incorporation of Salmon calcitonin, and further explored as protein carriers for oral delivery. Trimyristin SLN showed a mean size diameter of 200 nm with an association efficiency for calcitonin of approx. 86%. The morphology of SLN was investigated by cryo-SEM and by AFM, revealing spheroid shape SLN with a smooth surface. The in vitro release of calcitonin occurred for a period of 8 h, under both gastric and intestinal simulated pH conditions, predicting suitable properties for oral administration. The pharmacological activity of the protein was evaluated following oral dosage of calcitonin-loaded SLN in rats. SLN lowered the basal blood calcium levels by up to 20% with 500 IU/kg dose sustaining hypocalcaemia over 8 h. The results indicate that incorporation of Salmon calcitonin into trimyristin SLN is a key factor for the improvement of the efficiency of such carriers for oral delivery of proteins.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1166/jbn.2009.443pt_PT
dc.identifier.eissn1550-7041
dc.identifier.issn1550-7033
dc.identifier.urihttp://hdl.handle.net/10284/9893
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectSalmon calcitoninpt_PT
dc.subjectSCTpt_PT
dc.subjectSolid lipid nanoparticlespt_PT
dc.subjectSLNpt_PT
dc.subjectOral deliverypt_PT
dc.subjectProtein deliverypt_PT
dc.subjectTrimyristinpt_PT
dc.subjectHypocalcemic effecpt_PT
dc.titleImproving oral absorption of samon calcitonin by trimyristin lipid nanoparticlespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage8pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Biomedical Nanotechnologypt_PT
oaire.citation.volume4pt_PT
person.familyNameSilva
person.familyNameSouto
person.givenNameAna Catarina
person.givenNameEliana B.
person.identifier953153
person.identifier.ciencia-id5C1D-ED22-0D64
person.identifier.ciencia-id8D1B-21CC-90F7
person.identifier.orcid0000-0001-6923-0232
person.identifier.orcid0000-0002-9737-6017
person.identifier.ridF-1875-2017
person.identifier.ridL-9813-2014
person.identifier.scopus-author-id57028697500
person.identifier.scopus-author-id8839435500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67e7f707-32ec-444a-a20d-a17f8e6e7c21
relation.isAuthorOfPublicationb9f031fa-7f68-4196-b9c6-9f17cd542f12
relation.isAuthorOfPublication.latestForDiscovery67e7f707-32ec-444a-a20d-a17f8e6e7c21

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