Publication
Improving oral absorption of samon calcitonin by trimyristin lipid nanoparticles
| dc.contributor.author | Martins, S. | |
| dc.contributor.author | Silva, Ana Catarina | |
| dc.contributor.author | Ferreira, D.C. | |
| dc.contributor.author | Souto, Eliana B. | |
| dc.date.accessioned | 2021-05-06T14:06:13Z | |
| dc.date.available | 2021-05-06T14:06:13Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | Solid lipid nanoparticles (SLN) composed of trimyristin (solid lipid) and poloxamer 407 (surfactant) were prepared by a w/o/w emulsion technique for the incorporation of Salmon calcitonin, and further explored as protein carriers for oral delivery. Trimyristin SLN showed a mean size diameter of 200 nm with an association efficiency for calcitonin of approx. 86%. The morphology of SLN was investigated by cryo-SEM and by AFM, revealing spheroid shape SLN with a smooth surface. The in vitro release of calcitonin occurred for a period of 8 h, under both gastric and intestinal simulated pH conditions, predicting suitable properties for oral administration. The pharmacological activity of the protein was evaluated following oral dosage of calcitonin-loaded SLN in rats. SLN lowered the basal blood calcium levels by up to 20% with 500 IU/kg dose sustaining hypocalcaemia over 8 h. The results indicate that incorporation of Salmon calcitonin into trimyristin SLN is a key factor for the improvement of the efficiency of such carriers for oral delivery of proteins. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1166/jbn.2009.443 | pt_PT |
| dc.identifier.eissn | 1550-7041 | |
| dc.identifier.issn | 1550-7033 | |
| dc.identifier.uri | http://hdl.handle.net/10284/9893 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Salmon calcitonin | pt_PT |
| dc.subject | SCT | pt_PT |
| dc.subject | Solid lipid nanoparticles | pt_PT |
| dc.subject | SLN | pt_PT |
| dc.subject | Oral delivery | pt_PT |
| dc.subject | Protein delivery | pt_PT |
| dc.subject | Trimyristin | pt_PT |
| dc.subject | Hypocalcemic effec | pt_PT |
| dc.title | Improving oral absorption of samon calcitonin by trimyristin lipid nanoparticles | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 8 | pt_PT |
| oaire.citation.issue | 4 | pt_PT |
| oaire.citation.startPage | 1 | pt_PT |
| oaire.citation.title | Journal of Biomedical Nanotechnology | pt_PT |
| oaire.citation.volume | 4 | pt_PT |
| person.familyName | Silva | |
| person.familyName | Souto | |
| person.givenName | Ana Catarina | |
| person.givenName | Eliana B. | |
| person.identifier | 953153 | |
| person.identifier.ciencia-id | 5C1D-ED22-0D64 | |
| person.identifier.ciencia-id | 8D1B-21CC-90F7 | |
| person.identifier.orcid | 0000-0001-6923-0232 | |
| person.identifier.orcid | 0000-0002-9737-6017 | |
| person.identifier.rid | F-1875-2017 | |
| person.identifier.rid | L-9813-2014 | |
| person.identifier.scopus-author-id | 57028697500 | |
| person.identifier.scopus-author-id | 8839435500 | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 67e7f707-32ec-444a-a20d-a17f8e6e7c21 | |
| relation.isAuthorOfPublication | b9f031fa-7f68-4196-b9c6-9f17cd542f12 | |
| relation.isAuthorOfPublication.latestForDiscovery | 67e7f707-32ec-444a-a20d-a17f8e6e7c21 |
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