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Revisão narrativa: modulação da dor orofacial pelo sistema adenosinérgico – estratégias terapêuticas
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| Projeto de pós-graduação_38417 | 927.54 KB | Adobe PDF |
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Abstract(s)
Esta dissertação explora o papel complexo dos recetores adenosinérgicos na modulação da dor orofacial, identificando potenciais alvos terapêuticos para tratamentos mais eficazes e menos dependentes de opioides. A investigação destaca os recetores de adenosina, em particular, a ativação seletiva dos recetores A2A e A3, que demonstrou uma capacidade promissora na modulação dos processos inflamatórios e da perceção da dor. Esta revisão realça a importância de desenvolver intervenções analgésicas que explorem as vias adenosinérgicas, com um potencial significativo para melhorar a gestão da dor crónica em medicina dentária. Contudo, são identificados desafios importantes, como a necessidade de uma validação clínica robusta e a tradução dos resultados pré-clínicos em terapias aplicáveis, apelando para a realização de ensaios clínicos que avaliem a eficácia e segurança desses moduladores. Em conclusão, o sistema adenosinérgico revela-se um alvo promissor para a modulação da dor, através da adenosina ou dos seus agonistas, os quais podem apresentar menos efeitos adversos, embora os resultados até agora sejam pouco conclusivos. Este caminho continua a ser de grande interesse a ser explorado no futuro, seja como complemento a um tratamento clássico atual, permitindo a administração de doses menores, ou como uma alternativa terapêutica independente. No entanto, é de lamentar a escassez de estudos clínicos realizados nesta área, o que atualmente impede a integração da modulação da dor pelo sistema adenosinérgico na prática odontológica diária.
This dissertation explores the complex role of adenosine receptors in modulating orofacial pain, identifying potential therapeutic targets for more effective treatments that are less reliant on opioids. The research highlights adenosine receptors, particularly the selective activation of A2A and A3 receptors, which has shown promising potential in modulating inflammatory processes and pain perception. This review emphasizes the importance of developing analgesic interventions that leverage adenosine pathways, with significant potential to improve chronic pain management in dentistry. However, significant challenges are identified, such as the need for robust clinical validation and the translation of preclinical results into applicable therapies, calling for clinical trials to assess the efficacy and safety of these modulators. In conclusion, the adenosine system emerges as a promising target for pain modulation through adenosine or its agonists, which may present fewer adverse effects, although the results so far are inconclusive. This area remains of great interest for future exploration, either as a complement to current conventional treatment—allowing for lower doses—or as an independent therapeutic alternative. However, the scarcity of clinical studies in this field is regrettable, as it currently hinders the integration of adenosine-mediated pain modulation into daily dental practice.
This dissertation explores the complex role of adenosine receptors in modulating orofacial pain, identifying potential therapeutic targets for more effective treatments that are less reliant on opioids. The research highlights adenosine receptors, particularly the selective activation of A2A and A3 receptors, which has shown promising potential in modulating inflammatory processes and pain perception. This review emphasizes the importance of developing analgesic interventions that leverage adenosine pathways, with significant potential to improve chronic pain management in dentistry. However, significant challenges are identified, such as the need for robust clinical validation and the translation of preclinical results into applicable therapies, calling for clinical trials to assess the efficacy and safety of these modulators. In conclusion, the adenosine system emerges as a promising target for pain modulation through adenosine or its agonists, which may present fewer adverse effects, although the results so far are inconclusive. This area remains of great interest for future exploration, either as a complement to current conventional treatment—allowing for lower doses—or as an independent therapeutic alternative. However, the scarcity of clinical studies in this field is regrettable, as it currently hinders the integration of adenosine-mediated pain modulation into daily dental practice.
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Keywords
Recetores adenosinérgicos Adenosina Modulação da dor Dor orofacial Adenosinergic receptors Adenosine Pain modulation Orofacial pain