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Publication
Reacções teciduais na movimentação dentária induzida
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_37442 | 278.09 KB | Adobe PDF |
Advisor(s)
Abstract(s)
O movimento dentário ortodôntico baseia-se na reabsorção coordenada dos tecidos e na formação do osso circundante e do ligamento periodontal. O movimento dentário induzido causa hipóxia local e fluxo de fluidos gengivais, iniciando uma cascata inflamatória asséptica, culminando na reabsorção causada pelos osteoclastos em áreas de compressão e deposição de osteoblastos em áreas de tensão. A compressão e a tensão estão associadas a determinados fatores de sinalização, estabelecendo gradientes locais para regular a remodelação do osso e o ligamento periodontal no deslocamento dentário. Os principais reguladores da inflamação incluem citocinas, prostaglandinas, fatores de necrose tecidual entre outros. A inflamação ocorrida durante a movimentação dentária precisa ser bem controlada, uma vez que a inflamação desregulada leva à destruição tecidual manifesta na reabsorção radicular induzida por tratamento ortodôntico. Perceber a biologia tem profundas implicações clínicas, especialmente aos principais biomarcadores e agentes mediadores que estão envolvidos na inflamação asséptica induzida pelo movimento dentário.
Orthodontic tooth movement is based on the coordinated reabsorption of tissues and the formation of the surrounding bone and periodontal ligament. Induced tooth movement causes local hypoxia and gingival fluid flow, initiating an aseptic inflammatory cascade, culminating in the resorption caused by osteoclasts in areas of compression and deposition of osteoblasts in areas of tension. Compression and tension are associated with certain signaling factors, establishing local gradients to regulate bone remodeling and the periodontal ligament for tooth dislocation. The major regulators of inflammation include cytokines, prostaglandins, tissue necrosis factors, and others. The inflammation occurring during tooth movement needs to be well controlled, since unregulated inflammation leads to manifest tissue destruction in root resorption induced by orthodontic treatment and in periodontal disease. Understanding biology has profound clinical implications, especially the major biomarkers and mediating agents which are involved in aseptic inflammation induced by dental movement.
Orthodontic tooth movement is based on the coordinated reabsorption of tissues and the formation of the surrounding bone and periodontal ligament. Induced tooth movement causes local hypoxia and gingival fluid flow, initiating an aseptic inflammatory cascade, culminating in the resorption caused by osteoclasts in areas of compression and deposition of osteoblasts in areas of tension. Compression and tension are associated with certain signaling factors, establishing local gradients to regulate bone remodeling and the periodontal ligament for tooth dislocation. The major regulators of inflammation include cytokines, prostaglandins, tissue necrosis factors, and others. The inflammation occurring during tooth movement needs to be well controlled, since unregulated inflammation leads to manifest tissue destruction in root resorption induced by orthodontic treatment and in periodontal disease. Understanding biology has profound clinical implications, especially the major biomarkers and mediating agents which are involved in aseptic inflammation induced by dental movement.
Description
Keywords
Movimento dentário ortodôntico Reabsorção óssea Reabsorção óssea Ligamento periodontal Movimento dentário ortodôntico induzido Orthodontic tooth movement Bone resorption Periodontal dental ligament Induced tooth orthodontic movement