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Repeated administration of d-amphetamine results in a time-dependent and dose-independent sustained increase in urinary excretion of p-hydroxyamphetamine in mice

2007Journal article Restricted access
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dc.contributor.authorCarvalho, Félix
dc.contributor.authorSoares, Maria Elisa
dc.contributor.authorFernandes, Eduarda
dc.contributor.authorRemião, Fernando
dc.contributor.authorCarvalho, Márcia
dc.contributor.authorDuarte, José Alberto
dc.contributor.authorPires-das-Neves, Ricardo
dc.contributor.authorPereira, Maria de Lourdes
dc.contributor.authorBastos, Maria de Lourdes
dc.date.accessioned2021-07-05T09:19:29Z
dc.date.available2021-07-05T09:19:29Z
dc.date.issued2007
dc.description.abstractThe biotransformation of d-amphetamine into p-hydroxyamphetamine (HA) by cytochrome P450 occurs in several species besides humans. The extent of HA excretion varies among species and the oxidative pathway involved in this biotransformation is reported to be implicated in the toxic effects of d-amphetamine. The aim of this study was to evaluate the influence of dose and repeated administration of d-amphetamine on the urinary excretion of d-amphetamine and HA in mice. Charles River Caesarian Derived (CD)-1 mice, kept in metabolic cages, were treated with d-amphetamine (5, 10 and 20 mg/kg, i.p., daily, for 14 days). Urine was collected at 24 hr intervals and analyzed by HPLC for the quantification of d-amphetamine and HA. Urinary excretion of d-amphetamine increased in a dose dependent manner, the urinary levels being fairly constant after the 4th day. On the other hand the urinary excretion of HA increased during the whole time of d-amphetamine dosing and was not dose dependent. Cortical tubule degeneration was observed for the two higher doses, which may explain the HA excretion pattern, although inhibition of cytochrome P450 (CYP) after high d-amphetamine dosing may also be involved.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1248/jhs.53.371pt_PT
dc.identifier.eissn1347-5207
dc.identifier.issn1344-9702
dc.identifier.urihttp://hdl.handle.net/10284/10051
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationAmphetamines and physical exercise. An hazardous combination?
dc.subjectd-amphetaminept_PT
dc.subjectp-hydroxyamphetaminept_PT
dc.subjectMetabolismpt_PT
dc.subjectMicept_PT
dc.subjectHumanspt_PT
dc.titleRepeated administration of d-amphetamine results in a time-dependent and dose-independent sustained increase in urinary excretion of p-hydroxyamphetamine in micept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAmphetamines and physical exercise. An hazardous combination?
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCTI%2FACT%2F43562%2F2001/PT
oaire.citation.endPage377pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage371pt_PT
oaire.citation.titleJournal of Health Sciencept_PT
oaire.citation.volume53pt_PT
oaire.fundingStreamPOCI
person.familyNameCarvalho
person.givenNameMarcia
person.identifier2017111
person.identifier.ciencia-id8B10-171E-E63E
person.identifier.orcid0000-0001-9884-4751
person.identifier.ridD-5999-2013
person.identifier.scopus-author-id7201413997
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3837b828-ba57-47f7-a811-cce65e4922c6
relation.isAuthorOfPublication.latestForDiscovery3837b828-ba57-47f7-a811-cce65e4922c6
relation.isProjectOfPublication35dcaef6-8ae8-4d6c-bfc1-7a202d0cafa8
relation.isProjectOfPublication.latestForDiscovery35dcaef6-8ae8-4d6c-bfc1-7a202d0cafa8

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