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Publication
The relevance of natural compounds in the Alzheimer´s Disease
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Advisor(s)
Abstract(s)
A incidência da doença de Alzheimer (DA), uma doença neurodegenerativa, é
promovida pelo aumento da idade. Esta doença afeta a memória e outras funções
cognitivas com intensidade suficiente para produzir uma perda funcional. É a causa
mais comum de demência em idosos. O aumento contínuo da incidência da DA exige o
desenvolvimento urgente de uma terapêutica. Embora os estudos sobre essa doença
estejam a avançar rapidamente, até o momento, poucos medicamentos para retardar a
progressão da doença estão disponíveis no mercado. Nas últimas décadas, vários
compostos com diversas atividades farmacológicas extraídas de frutas, vegetais e ervas
demonstraram ter uma potencial eficácia contra a DA por meio de múltiplas alterações
patológicas da doença. A diversidade de compostos bioativos presentes nesses produtos
naturais desempenha um papel crucial na prevenção e no tratamento da DA.
The incidence of Alzheimer’s disease (AD), a neurodegenerative disease, is promoted by the increase of the age. This disease affects the memory and other cognitive functions with sufficient intensity to produce a functional loss, and it is the most common cause of dementia in the elderly. The continuous increase in the incidence of AD demands the urgent development of new therapies. Although, studies on this disease are advancing quickly, until the moment just few drugs to delay the progression of the disease are available for the patients. In recent decades, a number of compounds with diverse pharmacological activities extracted from fruits, vegetables and herbs demonstrated to have potential efficacies against AD via targeting multiple pathological changes of this disease. The diverse array of bioactive compounds presented in these natural products plays a crucial role in prevention and treatment of AD.
The incidence of Alzheimer’s disease (AD), a neurodegenerative disease, is promoted by the increase of the age. This disease affects the memory and other cognitive functions with sufficient intensity to produce a functional loss, and it is the most common cause of dementia in the elderly. The continuous increase in the incidence of AD demands the urgent development of new therapies. Although, studies on this disease are advancing quickly, until the moment just few drugs to delay the progression of the disease are available for the patients. In recent decades, a number of compounds with diverse pharmacological activities extracted from fruits, vegetables and herbs demonstrated to have potential efficacies against AD via targeting multiple pathological changes of this disease. The diverse array of bioactive compounds presented in these natural products plays a crucial role in prevention and treatment of AD.
Description
Keywords
Doença de Alzheimer Doenças neurodegenerativas Compostos naturais Alzheimer´s disease Neurodegenerative diseases Natural compounds