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A panel of urinary volatile biomarkers for differential diagnosis of prostate cancer from other urological cancers

2020Journal article Open access
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dc.contributor.authorLima, Ana Rita
dc.contributor.authorPinto, Joana
dc.contributor.authorCarvalho-Maia, Carina
dc.contributor.authorJerónimo, Carmen
dc.contributor.authorHenrique, Rui
dc.contributor.authorBastos, Maria de Lourdes
dc.contributor.authorCarvalho, Márcia
dc.contributor.authorGuedes de Pinho, Paula
dc.date.accessioned2021-07-02T10:43:22Z
dc.date.available2021-07-02T10:43:22Z
dc.date.issued2020
dc.description.abstractOur group recently developed a urinary 6-biomarker panel for the diagnosis of prostate cancer (PCa) which has a higher level of accuracy compared to the serum prostate specific antigen (PSA) test. Herein, urine from an independent cohort of PCa patients and cancer-free controls was analyzed to further validate the discriminative power of that panel. Additionally, urine from patients diagnosed with bladder cancer (BC) and renal cancer (RC) were included to evaluate the site-specificity of the panel. Results confirmed the ability of the 6-biomarker panel to discriminate PCa patients from controls, but not from other urological cancers. To overcome this limitation, an untargeted approach was performed to unveil discriminant metabolites among the three cancer types. A 10-biomarker panel comprising the original panel plus four new metabolites was established to discriminate PCa from controls, BC, and RC, with 76% sensitivity, 90% specificity, and 92% accuracy. This improved panel also disclosed better accuracy than serum PSA test and provides the basis for a new non-invasive early detection tool for PCa.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/cancers12082017pt_PT
dc.identifier.eissn2072-6694
dc.identifier.urihttp://hdl.handle.net/10284/10015
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationThis work was financed by national funds from FCT (UIDB/04378/2020) and PTDC/SAU-SER/30388/2017 project.pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectProstate cancerpt_PT
dc.subjectRenal cancerpt_PT
dc.subjectBladder cancerpt_PT
dc.subjectVolatile organic compoundspt_PT
dc.subjectUrinary biomarkerspt_PT
dc.subjectDetectionpt_PT
dc.titleA panel of urinary volatile biomarkers for differential diagnosis of prostate cancer from other urological cancerspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue8pt_PT
oaire.citation.startPage2017pt_PT
oaire.citation.titleCancerspt_PT
oaire.citation.volume12pt_PT
person.familyNameCarvalho
person.givenNameMarcia
person.identifier2017111
person.identifier.ciencia-id8B10-171E-E63E
person.identifier.orcid0000-0001-9884-4751
person.identifier.ridD-5999-2013
person.identifier.scopus-author-id7201413997
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3837b828-ba57-47f7-a811-cce65e4922c6
relation.isAuthorOfPublication.latestForDiscovery3837b828-ba57-47f7-a811-cce65e4922c6

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