Repository logo
 
Publication

Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles

1998Journal article Restricted access
Simple item page
dc.contributor.authorde Castro, Baltazar
dc.contributor.authorGameiro, Paula
dc.contributor.authorGuimarães, Carla
dc.contributor.authorLima, José L.F.C
dc.contributor.authorReis, Salette
dc.date.accessioned2019-11-27T12:55:21Z
dc.date.available2019-11-27T12:55:21Z
dc.date.issued1998
dc.description.abstractThe effect of sodium dodecyl sulfate (SDS) micelles on the spectrofluorimetric intensities and on the solubility of two b-blockers (atenolol and nadolol) were studied at 25.090.1°C and I=0.1 M NaCl. From the dependence of these physical properties on SDS concentration it was possible to calculate the binding constants drug-micelle, and it was found that both techniques yield similar results for the binding constants, and that are in agreement with those calculated from the effect of micelles on the apparent acidity constants of the b-blockers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/S0731-7085(98)00211-8pt_PT
dc.identifier.issn0731-7085
dc.identifier.issn1873-264X
dc.identifier.urihttp://hdl.handle.net/10284/8258
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectb-blockerspt_PT
dc.subjectSDS micellespt_PT
dc.subjectSpectrofluorimetrypt_PT
dc.subjectSolubilitypt_PT
dc.subjectBinding constantspt_PT
dc.titleFluorimetric and solubility studies of nadolol and atenolol in SDS micellespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage577pt_PT
oaire.citation.issue4-5pt_PT
oaire.citation.startPage573pt_PT
oaire.citation.titleJournal of Pharmaceutical and Biomedical Analysispt_PT
oaire.citation.volume18pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
J. Pharm. Biom. Anal. 1998.pdf
Size:
84.82 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCS - Artigos em Revistas Científicas Internacionais com Arbitragem Científica