Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles

de Castro, Baltazar; Gameiro, Paula; Guimarães, Carla; Lima, José L.F.C; Reis, Salette

http://hdl.handle.net/10284/8258

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Abstract(s)

The effect of sodium dodecyl sulfate (SDS) micelles on the spectroﬂuorimetric intensities and on the solubility of two b-blockers (atenolol and nadolol) were studied at 25.090.1°C and I=0.1 M NaCl. From the dependence of these physical properties on SDS concentration it was possible to calculate the binding constants drug-micelle, and it was found that both techniques yield similar results for the binding constants, and that are in agreement with those calculated from the effect of micelles on the apparent acidity constants of the b-blockers.