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Cervical cancer outcome and tumor-associated macrophages: research evidence

2022Journal article Restricted access
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dc.contributor.authorHorta, Bruno
dc.contributor.authorPereira, Tomé
dc.contributor.authorMedeiros, R.
dc.contributor.authorCerqueira, Fátima
dc.date.accessioned2022-07-29T12:12:30Z
dc.date.available2022-07-29T12:12:30Z
dc.date.issued2022
dc.description.abstractInflammation is a key factor in cancer promotion. Tumor-associated macrophages (TAMs), as part of the tumor microenvironment, are often associated with the progression of tumors and a worse prognosis in many cancers, namely on cervical cancer. This work exhaustively summarizes the conclusions of the different studies published concerning TAMs function in cervical cancer, from in vitro studies using cancer cell lines to the clinical perspective (histological samples-based studies). Most studies have led to the conclusion that TAMs increased density is directly related to increased severity of a malignant cervical lesion. Additionally, TAMs are normally polarized into an M2 phenotype, benefiting and promoting tumor progression, resulting in a worse disease outcome. The tumor microenvironment is also a highly critical contributor that not only influences tumor natural history but also modulates the specific immune response.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationHorta B, Pereira T, Medeiros R, Cerqueira F. Cervical Cancer Outcome and Tumor-Associated Macrophages: Research Evidence. Immuno. 2022; 2(3):460-468. https://doi.org/10.3390/immuno2030028pt_PT
dc.identifier.doi10.3390/immuno2030028pt_PT
dc.identifier.eissn2673-5601
dc.identifier.urihttp://hdl.handle.net/10284/11050
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.subjectCervical cancerpt_PT
dc.subjectCancer cell linespt_PT
dc.subjectCervical intraepithelial neoplasiapt_PT
dc.subjectSquamous intraepithelial lesionpt_PT
dc.subjectTumor-associated macrophagespt_PT
dc.subjectM1pt_PT
dc.subjectM2pt_PT
dc.titleCervical cancer outcome and tumor-associated macrophages: research evidencept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage468pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage460pt_PT
oaire.citation.titleImmunopt_PT
oaire.citation.volume2pt_PT
person.familyNameMedeiros
person.familyNameCerqueira
person.givenNameRui
person.givenNameFátima
person.identifier37604
person.identifier812695
person.identifier.ciencia-idC51F-5DBE-9C51
person.identifier.ciencia-idCF14-52ED-5DA0
person.identifier.orcid0000-0003-3010-8373
person.identifier.orcid0000-0003-4513-4654
person.identifier.ridC-7938-2009
person.identifier.ridM-7557-2013
person.identifier.scopus-author-id7006241641
person.identifier.scopus-author-id6603346911
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication5ffb7965-d9af-4ba1-a81b-b0aed28de206
relation.isAuthorOfPublication2705e35c-97f6-4de2-bbf1-d680342760e9
relation.isAuthorOfPublication.latestForDiscovery2705e35c-97f6-4de2-bbf1-d680342760e9

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