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Using the quality by design (QbD) approach to optimize formulations of lipid nanoparticles and nanoemulsions: a review

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dc.contributor.authorCunha, Sara
dc.contributor.authorCosta, Cláudia Pina
dc.contributor.authorMoreira, João Nuno
dc.contributor.authorLobo, José Manuel Sousa
dc.contributor.authorSilva, Ana Catarina
dc.date.accessioned2021-04-28T09:43:25Z
dc.date.available2021-04-28T09:43:25Z
dc.date.issued2020
dc.description.abstractQuality-by-design (QbD) approach has been applied to optimize lipid-based nanosystems formulations, including solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsions, besides being increasingly requested by regulatory authorities. Different mathematical models and statistical tests have been used, with similar conclusions regarding the parameters that influence the physical features of the resulting nanosystems. These include, variations in composition (e.g. lipid(s) and/or emulsifier(s)) and manufacturing parameters (e.g. emulsification rate and/or time, sonication amplitude and/or time, and homogenization pressure and/or cycles). These are critical parameters that influence nanoparticle/globule mean size, polydispersity index, zeta potential, drug encapsulation efficiency and in vitro drug release. This review addresses the concepts and applications of QbD for the development of lipid-based nanosystems, reporting successful examples published in the last 2 years. Although, some limitations have been identified, it is expected that in the upcoming years the application of QbD in pharmaceutical development will be an established approach.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.nano.2020.102206pt_PT
dc.identifier.issn1549-9634
dc.identifier.urihttp://hdl.handle.net/10284/9813
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectQuality by designpt_PT
dc.subjectOptimization of formulationspt_PT
dc.subjectSolid lipid nanoparticlespt_PT
dc.subjectNanostructured lipid carrierspt_PT
dc.subjectNanoemulsionspt_PT
dc.titleUsing the quality by design (QbD) approach to optimize formulations of lipid nanoparticles and nanoemulsions: a reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage17pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleNanomedicine: Nanotechnology, Biology and Medicinept_PT
oaire.citation.volume28pt_PT
person.familyNameSilva
person.givenNameAna Catarina
person.identifier953153
person.identifier.ciencia-id5C1D-ED22-0D64
person.identifier.orcid0000-0001-6923-0232
person.identifier.ridF-1875-2017
person.identifier.scopus-author-id57028697500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67e7f707-32ec-444a-a20d-a17f8e6e7c21
relation.isAuthorOfPublication.latestForDiscovery67e7f707-32ec-444a-a20d-a17f8e6e7c21

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