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Biomarkers in bladder cancer: a metabolomic approach using in vitro and ex vivo model systems

2016Journal article Restricted access
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dc.contributor.authorRodrigues, Daniela
dc.contributor.authorJerónimo, Carmen
dc.contributor.authorHenrique, Rui
dc.contributor.authorBelo, Luís
dc.contributor.authorBastos, Maria de Lourdes
dc.contributor.authorGuedes de Pinho, Paula
dc.contributor.authorCarvalho, Márcia
dc.date.accessioned2021-07-02T11:30:00Z
dc.date.available2021-07-02T11:30:00Z
dc.date.issued2016
dc.description.abstractMetabolomics has recently proved to be useful in the area of biomarker discovery for cancers in which early diagnostic and prognostic biomarkers are urgently needed, as is the case of bladder cancer (BC). This article presents a comprehensive review of the literature on the metabolomic studies on BC, highlighting metabolic pathways perturbed in this disease and the altered metabolites as potential biomarkers for BC detection. Current disease model systems used in the study of BC metabolome include in vitro-cultured cancer cells, ex vivo neoplastic bladder tissues and biological fluids, mainly urine but also blood serum/plasma, from BC patients. The major advantages and drawbacks of each model system are discussed. Based on available data, it seems that BC metabolic signature is mainly characterized by alterations in metabolites related to energy metabolic pathways, particularly glycolysis, amino acid and fatty acid metabolism, known to be crucial for cell proliferation, as well as glutathione metabolism, known to be determinant in maintaining cellular redox balance. In addition, purine and pyrimidine metabolism as well as carnitine species were found to be altered in BC. Finally, it is emphasized that, despite the progress made in respect to novel biomarkers for BC diagnosis, there are still some challenges and limitations that should be addressed in future metabolomic studies to ensure their translatability to clinical practice.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/ijc.30016pt_PT
dc.identifier.eissn1097-0215
dc.identifier.issn0020-7136
dc.identifier.urihttp://hdl.handle.net/10284/10021
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationNational Funds from FCT (Fundação para a Ciência e Tecnologia) and FEDER under Program PT2020; Grant number: Project 007265-UID/QUI/50006/2013.pt_PT
dc.subjectBladder cancerpt_PT
dc.subjectBiomarkerspt_PT
dc.subjectMetabolomicspt_PT
dc.subjectMetabolic pathwayspt_PT
dc.subjectReviewpt_PT
dc.subjectCell linespt_PT
dc.subjectTissuept_PT
dc.subjectUrinept_PT
dc.subjectSerumpt_PT
dc.subjectBiofluidspt_PT
dc.titleBiomarkers in bladder cancer: a metabolomic approach using in vitro and ex vivo model systemspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage268pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage256pt_PT
oaire.citation.titleInternational Journal of Cancerpt_PT
oaire.citation.volume139pt_PT
person.familyNameCarvalho
person.givenNameMarcia
person.identifier2017111
person.identifier.ciencia-id8B10-171E-E63E
person.identifier.orcid0000-0001-9884-4751
person.identifier.ridD-5999-2013
person.identifier.scopus-author-id7201413997
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3837b828-ba57-47f7-a811-cce65e4922c6
relation.isAuthorOfPublication.latestForDiscovery3837b828-ba57-47f7-a811-cce65e4922c6

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