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Personalised esomeprazole and ondansetron 3D printing formulations in Hospital Paediatric Environment: I-pre-formulation studies

2022Journal article Open access
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dc.contributor.authorFerreira, Mariana
dc.contributor.authorLopes, Carla Martins
dc.contributor.authorGonçalves, Hugo
dc.contributor.authorPinto, João F.
dc.contributor.authorCatita, José
dc.date.accessioned2024-01-30T15:11:22Z
dc.date.available2024-01-30T15:11:22Z
dc.date.issued2022
dc.description.abstractIndividualised medicine demands the formulation of pharmacotherapy in accordance with the characteristics of each patient’s health condition, and paediatrics is one of the areas that needs this approach. The 3D printing of oral doses is one method for achieving customised medicine in paediatrics. In this work, pre-formulation studies were conducted to evaluate the viability of using specific raw materials to produce 3D printed dosage forms based on two active pharmaceutical ingredients (APIs), ondansetron and esomeprazole, which are important for therapeutic customisation in paediatrics. Pre-formulation studies were carried out by characterising the physical and chemical properties of selected raw materials, selected APIs and their mixtures, using analytical methods such as scanning electron microscopy (SEM), X-ray powder diffraction (X-RPD), simultaneous thermal analysis (STA) and differential scanning calorimetry (DSC). The flowability of powders, compatibility and stability studies were also performed. Among all the ingredients selected, the PVPs (K17, K25 and K90) had the best characteristics to incorporate both forms of Esomeprazole Mg in a formulation to produce extrudates. The results obtained validated the use of some selected raw materials for tablet manufacture by the 3D printing approach.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira, M.; Lopes, C.M.; Gonçalves, H.; Pinto, J.F.; Catita, J. Personalised esomeprazole and ondansetron 3D printing formulations in Hospital Paediatric Environment: I-pre-formulation studies. Applied Sciences 2022, 12, 10585. https://doi.org/10.3390/ app122010585pt_PT
dc.identifier.doi10.3390/app122010585pt_PT
dc.identifier.eissn2076-3417
dc.identifier.urihttp://hdl.handle.net/10284/12627
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.subject3D printingpt_PT
dc.subjectPaediatricpt_PT
dc.subjectEsomeprazolept_PT
dc.subjectOndansetronpt_PT
dc.subjectPre-formulation studiespt_PT
dc.titlePersonalised esomeprazole and ondansetron 3D printing formulations in Hospital Paediatric Environment: I-pre-formulation studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue20pt_PT
oaire.citation.startPage10585pt_PT
oaire.citation.titleApplied Sciencespt_PT
oaire.citation.volume12pt_PT
person.familyNameLopes
person.familyNameMorais Catita
person.givenNameCarla
person.givenNameJose Antonio
person.identifierJose Catita
person.identifier.ciencia-id901D-160C-633E
person.identifier.ciencia-idB41E-3287-E706
person.identifier.orcid0000-0001-5080-032X
person.identifier.orcid0000-0001-7270-5702
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id26649517700
person.identifier.scopus-author-id6507275921
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublication24bb2971-32ae-429b-b397-145dacb66a5a
relation.isAuthorOfPublication.latestForDiscovery24bb2971-32ae-429b-b397-145dacb66a5a

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