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Probióticos e efeitos terapêuticos em patologias do sistema nervoso central
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| PPG_21792 | 465.12 KB | Adobe PDF |
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Abstract(s)
O trato gastrointestinal de um indivíduo saudável está colonizado por uma grande variedade e quantidade de microrganismos que compõem o microbiota intestinal, o qual desempenha um importante papel nos processos metabólicos, nutricionais, fisiológicos e imunológicos. Em situações de disbiose, resultante de desequilíbrios na composição ou função das espécies constituintes do microbiota, ocorrem alterações da função imunológica o que aumenta a suscetibilidade de desenvolver alergias, alterações metabólicas, doenças inflamatórias e doenças neurodegenerativas.
Os probióticos são suplementos alimentares contendo microrganismos vivos que, quando administrados em quantidades razoáveis, serão benéficos à saúde do seu consumidor ou hospedeiro. A sua administração exógena permite colonizar e estabilizar a composição da microflora, restabelecendo a sua função fisiológica vital, após desequilíbrios provocados pelo estilo de vida moderno e pelas várias doenças a ele associadas. Os
metabolitos produzidos por microrganismos probióticos através de diferentes mecanismos de ação, desempenham um importante papel na modulação imunológica e na manutenção da homeostase do microbiota.
O Eixo Microbiota-Intestino-Cérebro foi recentemente identificado com a descoberta de diversas vias hormonais e bioquímicas interligadas que relacionam o trato gastrointestinal e o cérebro. Este eixo desempenha um papel importante na regulação da saúde do hospedeiro, permitindo a comunicação bidirecional entre intestino e cérebro, o que sugere que o uso de probióticos poderá ter um forte potencial terapêutico no tratamento de doenças do sistema nervoso central como a Esclerose Múltipla, a Doença de Parkinson e a Doença de Alzheimer.
The gastrointestinal tract of a healthy individual is colonized by a wide variety and quantity of microorganisms that make up the intestinal microbiota, playing an important role in metabolic, nutritional, physiological and immunological processes. In situations of dysbiosis, resulting from imbalances in the composition or function of the species that make up the microbiota, immune function may be compromized, increasing the susceptibility of developing allergies, metabolic changes, inflammatory diseases and neurodegenerative diseases. Probiotics are food supplements containing live microorganisms that, when administered in reasonable amounts, will be beneficial to the health of their consumer or host. Its exogenous administration allows colonization and stabilization of the microflora composition, restoring its vital physiological function, after imbalance due to modern lifestyle and associated diseases. Probiotic metabolites, through diverse mechanisms of action, play an important role in immunological modulation and maintenance of microbiota homeostasis. The Microbiota-Gut-Brain Axis was recently identified with the discovery of several interconnected hormonal and biochemical pathways linking the gastrointestinal tract and the brain. This Axis plays an important role in the regulation of host health by allowing bidirectional communication between the intestine and the brain, thus suggesting probiotic use as a promising therapeutic strategy for the treatment of central nervous system diseases such as multiple sclerosis, Parkinson's disease and Alzheimer's disease.
The gastrointestinal tract of a healthy individual is colonized by a wide variety and quantity of microorganisms that make up the intestinal microbiota, playing an important role in metabolic, nutritional, physiological and immunological processes. In situations of dysbiosis, resulting from imbalances in the composition or function of the species that make up the microbiota, immune function may be compromized, increasing the susceptibility of developing allergies, metabolic changes, inflammatory diseases and neurodegenerative diseases. Probiotics are food supplements containing live microorganisms that, when administered in reasonable amounts, will be beneficial to the health of their consumer or host. Its exogenous administration allows colonization and stabilization of the microflora composition, restoring its vital physiological function, after imbalance due to modern lifestyle and associated diseases. Probiotic metabolites, through diverse mechanisms of action, play an important role in immunological modulation and maintenance of microbiota homeostasis. The Microbiota-Gut-Brain Axis was recently identified with the discovery of several interconnected hormonal and biochemical pathways linking the gastrointestinal tract and the brain. This Axis plays an important role in the regulation of host health by allowing bidirectional communication between the intestine and the brain, thus suggesting probiotic use as a promising therapeutic strategy for the treatment of central nervous system diseases such as multiple sclerosis, Parkinson's disease and Alzheimer's disease.
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Keywords
Microbiota Probióticos Eixo microbiota-intestino-cérebro Esclerose múltipla Doença de Parkinson Doença de Alzheimer Probiotics Microbiota-intestine-brain axis Multiple sclerosis Parkinson's disease Alzheimer's disease