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Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathy

2016Journal article Open access
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dc.contributor.authorLêdo, Susana
dc.contributor.authorLeite, Ângela
dc.contributor.authorSouto, Teresa
dc.contributor.authorDinis, Maria Alzira Pimenta
dc.contributor.authorSequeiros, Jorge
dc.date.accessioned2019-09-13T12:46:26Z
dc.date.available2019-09-13T12:46:26Z
dc.date.issued2016
dc.descriptionhttp://sherpa.ac.uk/romeo/search.php?issn=1809-452Xpt_PT
dc.description.abstractOBJECTIVE: To study anxiety as a variable of the mid- and long-term psychological impact of pre-symptomatic testing for three autosomal dominant late-onset disorders - Huntington's disease (HD), Machado-Joseph disease (MJD) and familial amyloid polyneuropathy (FAP) TTR V30M - in a Portuguese sample. METHODS: This cross-sectional study included 203 participants: 170 (83.7%) underwent pre-symptomatic testing for FAP, 29 (14.3%) for HD, and 4 (2%) for MJD. Of the 203 participants, 73 (36.0%) were asymptomatic carriers, 29 (14.5%) were symptomatic carriers, 9 (4.5%) were diagnosed with FAP and had a liver transplant, and 89 (44.5%) were non-carriers. Most were women (58.1%) and married (66.5%). The anxiety variable was assessed using the Zung Self-Rating Anxiety Scale (SAS). RESULTS: The anxiety scores were higher for symptomatic carriers and for those who underwent psychological support consultations over the years. For symptomatic carriers, the mean scores were superior to 40 points, which reflects clinical anxiety. CONCLUSION: Although it was not possible to differentiate between the mid- and long-term psychological impacts, this study supports the conclusion that the proximity to the age of symptoms onset might be a trigger for anxiety.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAPA: Lêdo, S., Leite, Â., Souto, T., Dinis, M. A., & Sequeiros, J. (2016). Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathy. Revista Brasileira de Psiquiatria, 38(2), 113-120. doi:10.1590/1516-4446-2014-1617pt_PT
dc.identifier.doi10.1590/1516-4446-2014-1617pt_PT
dc.identifier.issn1809-452X
dc.identifier.urihttp://hdl.handle.net/10284/7853
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAssociação Brasileira de Psiquiatriapt_PT
dc.relation.publisherversionhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000200113&lng=en&tlng=enpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectAmyloid Neuropathies, Familialpt_PT
dc.subjectAnxietypt_PT
dc.subjectAsymptomatic Diseasespt_PT
dc.subjectCross-Sectional Studiespt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectHuntington Diseasept_PT
dc.subjectMachado-Joseph Diseasept_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPortugalpt_PT
dc.subjectPredictive Value of Testspt_PT
dc.subjectSurveys and Questionnairespt_PT
dc.subjectTime Factorspt_PT
dc.titleMid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage120pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage113pt_PT
oaire.citation.titleRevista Brasileira de Psiquiatriapt_PT
oaire.citation.volume38pt_PT
person.familyNameLêdo
person.familyNameDinis
person.familyNameSequeiros
person.givenNameSusana
person.givenNameMaria Alzira Pimenta
person.givenNameJorge
person.identifier493603
person.identifier666710
person.identifier.ciencia-id4710-147D-FDAF
person.identifier.ciencia-id0E17-D288-38BC
person.identifier.orcid0000-0003-3083-3129
person.identifier.orcid0000-0002-2198-6740
person.identifier.orcid0000-0002-9846-1037
person.identifier.ridF-3309-2011
person.identifier.scopus-author-id55539804000
person.identifier.scopus-author-id55851941438
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf114f5ce-d79b-44be-96b4-2ab1bf364d28
relation.isAuthorOfPublication1e85592a-e8e2-4aea-bd8e-1007c94388c0
relation.isAuthorOfPublication20b11e35-c7b6-4c50-933c-320b4cab674c
relation.isAuthorOfPublication.latestForDiscovery1e85592a-e8e2-4aea-bd8e-1007c94388c0

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