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Inducing apoptosis in cancer therapy
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Every cell in a multicellular organism has the potential to die by apoptosis. Treatment of cancer cells with tumour necrosis factor - can induce an apoptotic signal leading to the death of these cells; however, many malignancies are resistant to the effects of TNF-α. Overexpression of FLIP, a protein that blocks the caspase activity of FLICE, mediates the observed resistance. Thus, FLIP, which normally prevents inappropriate apoptosis, may
become a tumour progression factor.
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Revista da Faculdade de Ciências da Saúde. Porto. ISSN 1646-0480. 2 (2005) 55-62.