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Publication
Fitoterapia aplicada ao tratamento da osteoporose
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_21960 | 1.4 MB | Adobe PDF |
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Advisor(s)
Abstract(s)
A osteoporose é uma patologia assintomática a nível do esqueleto, que se caracteriza pela perda de densidade mineral óssea e pela deterioração da microarquitectura do osso. Assim sendo, esta patologia tem como consequências o aumento da fragilidade óssea e o aumento da suscetibilidade a fraturas.
Com o envelhecimento da população a nível global, a osteoporose constitui atualmente, um problema de Saúde Pública grave. Esta doença, afeta ambos os sexos, no entanto as pessoas mais afetadas por ela são as mulheres, essencialmente no período pós-menopausa.
Atualmente o tratamento da osteoporose baseia-se no seu tratamento farmacológico associado a mudanças no estilo de vida, incluindo mudanças alimentares, suplementação alimentar e prática de exercício físico. Contudo, estima-se que cerca de 70% das mulheres abandonam o tratamento no primeiro ano devido aos efeitos secundários associados a este tratamento.
Assim sendo, a fitoterapia pode constituir uma alternativa aos problemas causados pela osteoporose. De facto a presença de compostos flavonoides e outros constituintes presentes nas plantas têm demonstrado uma ação benéfica na prevenção e tratamento da osteoporose. Para corroborar este facto achámos pertinente orientar o nosso estudo para cinco plantas distintas e muito utilizadas no tratamento fitoterápico da osteoporose: a cavalinha (Equisetum arvense), o cártamo (Carthamus tinctorius L.), o ligustro (Ligustrum lucidum), a soja (Glycine max L.) e a cimicifuga (Cimicifuga racemosa L.).
Osteoporosis is an asymptomatic skeletal disease characterized by the loss of mineral bone mass and microarchitectural deterioration of bone tissue. As a result, there is a consequent increase in bone fragility and a higher risk for fractures. Because of worldwide population aging, osteoporosis is currently a severe Public Health problem. It affects both genders, although women are most affected, especially in the postmenopausal period. Presently, the treatment for osteoporosis is based on drug therapy, as well as changes in lifestyle, including healthy dietary measures, dietary supplementation and physical exercice practice. However, it is estimated that nearly 70% of women abandon treatment during the first year, because of the side effects associated to most therapies. Phytotherapy may be an alternative to resolve problems caused by osteoporosis. In fact, the presence of flavanoid compounds and other constituents in plants have demonstrated benefits in the prevention and treatment of osteoporosis. In order to prove this, the authors found it pertinent to confine this study to five different plants that are widely used in phytotherapy for the treatment of osteoporosis: horsetail or bottle-bush (Equisetum arvense), safflower (Carthamus tinctorius L.), privet (Ligustrum lucidum), soy (Glycine max L.) and black cohosh (Cimicifuga racemosa L.).
Osteoporosis is an asymptomatic skeletal disease characterized by the loss of mineral bone mass and microarchitectural deterioration of bone tissue. As a result, there is a consequent increase in bone fragility and a higher risk for fractures. Because of worldwide population aging, osteoporosis is currently a severe Public Health problem. It affects both genders, although women are most affected, especially in the postmenopausal period. Presently, the treatment for osteoporosis is based on drug therapy, as well as changes in lifestyle, including healthy dietary measures, dietary supplementation and physical exercice practice. However, it is estimated that nearly 70% of women abandon treatment during the first year, because of the side effects associated to most therapies. Phytotherapy may be an alternative to resolve problems caused by osteoporosis. In fact, the presence of flavanoid compounds and other constituents in plants have demonstrated benefits in the prevention and treatment of osteoporosis. In order to prove this, the authors found it pertinent to confine this study to five different plants that are widely used in phytotherapy for the treatment of osteoporosis: horsetail or bottle-bush (Equisetum arvense), safflower (Carthamus tinctorius L.), privet (Ligustrum lucidum), soy (Glycine max L.) and black cohosh (Cimicifuga racemosa L.).
Description
Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas
Keywords
Osteoporose Remodelação óssea Cálcio e vitamina D Fitoterapia Equisetum arvense Carthamus tinctorius L. Ligustrum lucidum Glycine max L. Cimicifuga racemosa L. Osteoporosis Bone remodelling Calcium and vitamin D Phytotherapy Equisetum arvense Carthamus tinctorius L. Ligustrum lucidum Glycine max L. Cimicifuga racemosa L.