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The role of lipids in drug absorption throught the GIT

2008Journal article Open access
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dc.contributor.authorDoktorovova, Slavomira
dc.contributor.authorMorsy, Tarekpor
dc.contributor.authorBalcão, Victor
dc.contributor.authorSouto, Eliana B.
dc.date.accessioned2009-02-12T09:21:54Zpor
dc.date.accessioned2011-10-06T14:52:25Z
dc.date.available2009-02-12T09:21:54Zpor
dc.date.available2011-10-06T14:52:25Z
dc.date.issued2008por
dc.description.abstractOs vectores lipídicos apresentam inúmeras vantagens para a administração oral de substâncias farmacológicas, p.ex. são compostos por moléculas lipídicas semelhantes àquelas que figuram nos tecidos humanos, tornando-se biocompatíveis, biotoleráveis e biodegradáveis. São exemplos as tradicionais emulsões O/A, as suspensões de nanopartículas lipídicas (SLNs e NLC s) e, recentemente, as SolEmuls®, que permitem localizar fármacos fracamente solúveis em ambas as fases das emulsões, na camada interfacial de lecitina. Este artigo aborda o papel dos lípidos no aumento da absorção e da biodisponibilidade de fármacos administrados oralmente. Lipid carriers show several advantages for oral delivery of pharmacologically active drugs, e.g. are composed of lipid molecules similar to those in human tissues, becoming therefore biocompatible, biotolerable and biodegradable. Examples include traditional o/w emulsions, suspensions of lipid nanoparticles (SLNs and NLC s) and, recently, the SolEmuls®, which allows localizing poorly soluble drug molecules both in oil and aqueous phases, in the interfacial layer of lecithin. This paper reports on the role of lipids in enhancing both drug absorption and bioavailability when administered orally.por
dc.identifier.citationRevista da Faculdade de Ciências da Saúde. Porto. ISSN 1646-0480. 5 (2008) 192-199.por
dc.identifier.issn1646-0480por
dc.identifier.urihttp://hdl.handle.net/10284/932por
dc.language.isoengpor
dc.publisherEdições Universidade Fernando Pessoapor
dc.relation.ispartofseriesRevista da Faculdade de Ciências da Saúdepor
dc.relation.ispartofseries5por
dc.subjectAdministração oral de fármacospor
dc.subjectLipossomaspor
dc.subjectNanopartículas de lípidos sólidospor
dc.subjectVectores lipídicos nanoestruturadospor
dc.subjectOral drug deliverypor
dc.subjectLiposomespor
dc.subjectSolid lipid nanoparticlespor
dc.subjectNanostructured lipid carrierspor
dc.titleThe role of lipids in drug absorption throught the GITpor
dc.typejournal article
dspace.entity.typePublication
person.familyNameDoktorovova
person.familyNameBalcão
person.familyNameSouto
person.givenNameSlavomira
person.givenNameVictor
person.givenNameEliana B.
person.identifier366700
person.identifier.ciencia-idC314-A18C-931B
person.identifier.ciencia-id8D1B-21CC-90F7
person.identifier.orcid0000-0001-5607-0241
person.identifier.orcid0000-0003-0772-2834
person.identifier.orcid0000-0002-9737-6017
person.identifier.ridC-5890-2008
person.identifier.ridI-2182-2012
person.identifier.ridL-9813-2014
person.identifier.scopus-author-id26645513700
person.identifier.scopus-author-id6603449856
person.identifier.scopus-author-id8839435500
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication890a7977-2e87-40e7-928c-d4b77a081345
relation.isAuthorOfPublicationf84a6560-46a5-4a51-91e4-25ab97dd1319
relation.isAuthorOfPublicationb9f031fa-7f68-4196-b9c6-9f17cd542f12
relation.isAuthorOfPublication.latestForDiscoveryb9f031fa-7f68-4196-b9c6-9f17cd542f12

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FCS - Número 05 (2008)