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Processos degenerativos do tecido cutâneo: fisiopatologia, prevenção e tratamento
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_26263 | 1.01 MB | Adobe PDF |
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Advisor(s)
Abstract(s)
Os processos degenerativos do tecido cutâneo estão amplamente associados ao
seu envelhecimento natural, onde se verifica perda de tecido fibroso, renovação celular
mais lenta e redução da rede vascular e glandular da pele. Alguns fatores externos ao
organismo podem contudo acelerar estes processos, como por exemplo a exposição
solar, consumo excessivo de álcool e tabaco, poluição ambiental e aumento de peso.
De entre estes processos destacam-se o processo descamativo, um fenómeno
natural do mecanismo de diferenciação dos queratinócitos. É um processo complexo
que envolve essencialmente a degradação da coesão entre células da pele.
A lipodistrofia ginóide é outro destes processos, comummente denominado de
celulite, e que se caracteriza como uma distrofia celular complexa, com alterações do
metabolismo hídrico que conferem uma aparência de "casca de laranja" à pele.
A flacidez é um processo resultante da atrofia tecidular, onde se verifica a perda
progressiva de massa muscular que é substituída por tecido adiposo. Está diretamente
relacionada com a redução da produção de fibras de colagénio e fibras elásticas no
tecido subcutâneo.
Por fim, insuficiência venosa é um termo utilizado para caracterizar um processo
que afeta o sistema venoso dos membros inferiores, que se desenvolve por aumento da
pressão venosa em combinação com um retorno venoso ineficiente.
Embora ainda não exista compreensão total destes mecanismos, já é possível
encontrar uma série de tratamentos que visam minimizar ou mesmo tratá-los, de modo a
que não se agravem e representem um risco sério para a saúde.
The degenerative processes of the skin are widely associated with its natural aging, where occurs loss of fibrous tissue, slower cell turnover and reduce vascular network and glandular skin. Some factors outside the body can accelerate these processes, such as sun exposure, excessive alcohol and tobacco, environmental pollution and weight gain. These processes include the desquamation process, a natural phenomenon described as a stage of keratinocyte differentiation mechanism. It is a complex process that essentially involves the degradation of the cohesion of skin cells. The gynoid lipodystrophy is another process, characterized as a complex cellular dystrophy, with changes of water metabolism that leads to the appearance of "orange peel" skin. The sagging is a process resulting from tissue atrophy, where there is the progressive loss of muscle mass that is replaced by adipose tissue. It is directly related to the reduced production of collagen and elastic fibers in the subcutaneous tissue. Finally, venous insufficiency is a term used to describe a process that affects the venous system of the lower limbs, which involves an increased venous pressure in combination with an inefficient venous return. Although there is still no full understanding of these mechanisms, it is possible to find treatments to minimizing or even treat them so it doesn’t become worst or a serious health risk.
The degenerative processes of the skin are widely associated with its natural aging, where occurs loss of fibrous tissue, slower cell turnover and reduce vascular network and glandular skin. Some factors outside the body can accelerate these processes, such as sun exposure, excessive alcohol and tobacco, environmental pollution and weight gain. These processes include the desquamation process, a natural phenomenon described as a stage of keratinocyte differentiation mechanism. It is a complex process that essentially involves the degradation of the cohesion of skin cells. The gynoid lipodystrophy is another process, characterized as a complex cellular dystrophy, with changes of water metabolism that leads to the appearance of "orange peel" skin. The sagging is a process resulting from tissue atrophy, where there is the progressive loss of muscle mass that is replaced by adipose tissue. It is directly related to the reduced production of collagen and elastic fibers in the subcutaneous tissue. Finally, venous insufficiency is a term used to describe a process that affects the venous system of the lower limbs, which involves an increased venous pressure in combination with an inefficient venous return. Although there is still no full understanding of these mechanisms, it is possible to find treatments to minimizing or even treat them so it doesn’t become worst or a serious health risk.
Description
Keywords
Degeneração cutânea Lipodistrofia gonóide Descamação Flacidez Insuficiência venosa Skin degeneration Gynoid lipodystrophy Desquamation Sagging Venous insufficiency