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Publication
HPV- Cancro Oral (Vírus do Papiloma Humano)
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| PPG_25911 | 150.02 KB | Adobe PDF |
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Abstract(s)
Hoje em dia o Cancro Oral ocupa uma posição relevante na esfera da saúde pública, sendo mundialmente o sexto cancro mais comum. A identificação precoce é fundamental para a diminuição da prevalência de cancro oral.
Observou-se recentemente, que o genoma do vírus do Papiloma Humano está presente nos cancros da amígdala e da orofaringe, ainda que os fatores etiológicos predominantes sejam o tabaco e o álcool.
As infeções por este vírus são mais frequentes em jovens sexualmente ativos, contudo em apenas uma pequena fração de indivíduos infetados se desenvolve a infeção, o que implica o envolvimento de co-fatores ambientais e genéticos na carcinogénese.
Não são ainda conhecidos todos os mecanismos fisiopatológicos referentes à infeção pelo HPV ao nível da cavidade oral.
Na prevalência e progressão são classificados de alto risco alguns subtipos do Vírus do Papiloma Humano, particularmente os subtipos 16 e 18.
Grande parte dos estudos sugerem que pacientes com HPV positivo para carcinomas das células escamosas da cabeça e pescoço diferem dos HPV negativos em muitos aspetos. Os carcinomas HPV positivo têm um melhor prognóstico pois apresenta uma resposta mais benéfica à terapêutica, uma vez que incide em indivíduos mais jovens.
Este trabalho tem como objetivo abordar a importância da vacinação como prevenção nos casos de HPV ao nível da cavidade oral. Sendo esta a principal estratégia para a diminuição da prevalência do cancro oral e orofaríngeo.
Oral Cancer now occupies a prominent position in the public health sphere, being the sixth most common cancer worldwide. Early identification is key to a decrease in the prevalence of oral cancer. It has recently been observed that the human papillomavirus genome is present in amygdala and oropharyngeal cancers, although the predominant etiological factors are tobacco and alcohol. Infections by this virus are more conceptualized by young people and participate in an infection, which is an involvement of environmental and genetic co-factors in carcinogenesis. All pathophysiological mechanisms regarding HPV infection with money from the oral cavity are not yet known. In the prevalence and progress are classified as high risk, some subtypes of Human Papilloma Virus, particularly subtypes 16 and 18. Much of the studies suggest that patients with HPV positive for squamous cell carcinomas of the head and neck differ from HPV-negative in many respects. Positive HPV carcinomas have a better prognosis to present a more beneficial response in therapy, since it affects younger individuals. This work aims to address the importance of vaccination as a prevention in cases of HPV in the open air of the oral cavity. It is a major strategy for decreasing the prevalence of cancer and oropharyngeal.
Oral Cancer now occupies a prominent position in the public health sphere, being the sixth most common cancer worldwide. Early identification is key to a decrease in the prevalence of oral cancer. It has recently been observed that the human papillomavirus genome is present in amygdala and oropharyngeal cancers, although the predominant etiological factors are tobacco and alcohol. Infections by this virus are more conceptualized by young people and participate in an infection, which is an involvement of environmental and genetic co-factors in carcinogenesis. All pathophysiological mechanisms regarding HPV infection with money from the oral cavity are not yet known. In the prevalence and progress are classified as high risk, some subtypes of Human Papilloma Virus, particularly subtypes 16 and 18. Much of the studies suggest that patients with HPV positive for squamous cell carcinomas of the head and neck differ from HPV-negative in many respects. Positive HPV carcinomas have a better prognosis to present a more beneficial response in therapy, since it affects younger individuals. This work aims to address the importance of vaccination as a prevention in cases of HPV in the open air of the oral cavity. It is a major strategy for decreasing the prevalence of cancer and oropharyngeal.
Description
Keywords
Vírus do papiloma humano Carcinoma das células escamosas da cabeça e pescoço Vacinação para HPV Epidemiologia carcinogénese Human papilloma virus Squamous cell carcinoma of the head and neck Vaccination for HPV Epidemiology carcinogenesis