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The GLP-1 system: biochemistry physiological effects and the role of DDP-IV inhibitors in the management of type 2 diabetes mellitus

2010Journal article Open access
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dc.contributor.authorAndreani, Tatiana
dc.contributor.authorSilva, Amélia M.
dc.contributor.authorSouza, Ana Luiza R. de
dc.date.accessioned2012-04-23T08:40:40Z
dc.date.available2012-04-23T08:40:40Z
dc.date.issued2010
dc.description.abstractType-2 diabetes mellitus (T2DM) is a metabolic disease characterized mainly by hyperglycemia, resulting from defects in β-cell function and/or insulin resistance. Treatment approaches include diet, exercise, and pharmacological agents these however can produce adverse effects such as weight gain and hypoglycemia. Glucagon-like peptide-1 (GLP-1) is a peptide hormone that controls glycaemia and preserves β-cell mass and function. Currently dipeptidyl peptidase (DDP-IV) inhibitors are a new class of anti-diabetics for the treatment of T2DM, prolonging GLP-1 action on insulin release. A Diabetes mellitus tipo-2 (DMT2), é uma doença metabólica caracterizada por hiperglicemia, devido à disfunção das células-β e/ou resistência à insulina. Os tratamentos disponíveis além de dieta e exercício físico, incluem terapia farmacológica com possíveis efeitos colaterais tais como ganho de peso e hipoglicemia. O Glucagon-like peptide-1 (GLP-1) é uma hormona peptídica que controla a glicemia, preserva e previne a perda das células-β mas é rapidamente degradada pela dipeptidyl peptidase-IV (DDP-IV). Os Inibidores da DDP-IV têm sido propostos para tratamento da DMT2, dado prolongarem a acção de GLP-1 na libertação de insulina e controle glicémico.por
dc.identifier.citationRevista da Faculdade de Ciências da Saúde. Porto: Edições Universidade Fernando Pessoa. ISSN 1646-0480. 7 (2010) 234-244.por
dc.identifier.issn1646-0480
dc.identifier.urihttp://hdl.handle.net/10284/2973
dc.language.isoengpor
dc.publisherEdições Universidade Fernando Pessoapor
dc.relation.ispartofseriesRevista da Faculdade de Ciências da Saúde;7 (2010)
dc.subjectGLP-1por
dc.subjectGlucagon-like peptide-1por
dc.subjectDDP-IVpor
dc.subjectDDP-IV inhibitorspor
dc.subjectDiabetes mellitus type 2por
dc.subjectInibidor da DDP-IVpor
dc.subjectDiabetes mellitus tipo 2por
dc.titleThe GLP-1 system: biochemistry physiological effects and the role of DDP-IV inhibitors in the management of type 2 diabetes mellituspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage244por
oaire.citation.startPage234por
person.familyNameAndreani
person.familyNameSilva
person.givenNameTatiana
person.givenNameAmélia
person.identifier1251023
person.identifier447329
person.identifier.ciencia-idF71E-31F5-DF0A
person.identifier.ciencia-id241E-3956-0242
person.identifier.orcid0000-0002-3794-8159
person.identifier.orcid0000-0002-7524-9914
person.identifier.ridJ-7128-2013
person.identifier.scopus-author-id36656962100
person.identifier.scopus-author-id35578752300
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication309e30db-3803-438f-be32-8e0cbc290e02
relation.isAuthorOfPublication6f7e2203-6bb4-43d8-99cd-10ec88750b4c
relation.isAuthorOfPublication.latestForDiscovery6f7e2203-6bb4-43d8-99cd-10ec88750b4c

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FCS - Número 07 (2010)