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Biofunctionalization of the implant to prevent peri-implantitis
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| Projeto de pós-graduação_2022100537 | 719.73 KB | Adobe PDF |
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Abstract(s)
Os implantes de titânio são utilizados para substituir dentes em falta, sendo o titânio o padrão de ouro devido à sua capacidade de osseointegração. O sucesso dos implantes depende principalmente da osseointegração, mas também da prevenção de complicações biológicas tardias, conhecidas como "peri-implantite", uma das causas mais comuns de perda de implantes devido à colonização bacteriana.
Recentemente, o desenvolvimento de superfícies bioactivas de implantes provou ser eficaz na melhoria da osteointegração. Além disso, foi relatado que a biofuncionalização possui atividade antibacteriana. O que leva à seguinte questão, à qual esta revisão pretende responder: A biofuncionalização de implantes dentários previne o desenvolvimento de peri-implantite?
Para realizar esta revisão integrativa, foram pesquisadas as seguintes bases de dados: PubMed, Medline, Scopus, Cochrane Central Register of Controlled Trials, e Science Direct.
22 artigos preencheram os critérios de inclusão: 1 ensaio clínico aleatório, 12 estudos in vitro e 10 artigos que combinavam estudos experimentais in vitro e in vivo.
Todos os estudos relataram a redução do acúmulo de biofilme e a regulação positiva da resposta celular.
No que diz respeito às superfícies bioactivas investigadas, os iões metálicos e as nanopartículas foram as superfícies bioactivas mais frequentemente utilizadas. De acordo com os resultados desta revisão integrativa, as superfícies bioactivas têm um efeito positivo na prevenção da peri-implantite. É necessário uma investigação mais aprofundada neste campo para avaliar o seu efeito sustentável para combater o processo crónico da peri-implantite.
Titanium implants are used to replace missing teeth, with titanium representing the gold standard due to its ability to provide osseointegration. The success of implants depends on osseointegration primarily, but also on the prevention of late biological complications, known as “peri-implantitis”, one of the most common causes of implant loss due to bacterial colonization. Recently, the development of bioactive surfaces of implants proved effective in enhancing osseointegration. Furthermore, biofunctionalization was reported to possess antibacterial activity. Which leads to the following question to which this review aims answering: Does biofunctionalization of dental implants prevent the development of peri-implantitis? To conduct this integrative review, the following databases have been searched: PubMed, Medline, Scopus, Cochrane Central Register of Controlled Trials, and Science Direct. 22 articles met the inclusion criteria: 1 randomized clinical trial, 12 in vitro studies, and 10 articles combining in vitro and in vivo experimental studies. All studies reported reduction of biofilm accumulation and upregulation of cellular response. Regarding the bioactive surfaces investigated, metallic ions and nanoparticles were the most frequently used bioactive surfaces. According to the results of this integrative review, bioactive surfaces have a positive effect on the prevention of peri-implantitis. Further and more in-depth research in this field is required to evaluate its sustainable effect to match the chronic process of peri-implantitis.
Titanium implants are used to replace missing teeth, with titanium representing the gold standard due to its ability to provide osseointegration. The success of implants depends on osseointegration primarily, but also on the prevention of late biological complications, known as “peri-implantitis”, one of the most common causes of implant loss due to bacterial colonization. Recently, the development of bioactive surfaces of implants proved effective in enhancing osseointegration. Furthermore, biofunctionalization was reported to possess antibacterial activity. Which leads to the following question to which this review aims answering: Does biofunctionalization of dental implants prevent the development of peri-implantitis? To conduct this integrative review, the following databases have been searched: PubMed, Medline, Scopus, Cochrane Central Register of Controlled Trials, and Science Direct. 22 articles met the inclusion criteria: 1 randomized clinical trial, 12 in vitro studies, and 10 articles combining in vitro and in vivo experimental studies. All studies reported reduction of biofilm accumulation and upregulation of cellular response. Regarding the bioactive surfaces investigated, metallic ions and nanoparticles were the most frequently used bioactive surfaces. According to the results of this integrative review, bioactive surfaces have a positive effect on the prevention of peri-implantitis. Further and more in-depth research in this field is required to evaluate its sustainable effect to match the chronic process of peri-implantitis.
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Keywords
Antibacteriano Revestimento bioativo Biofuncionalização Peri-implantite Tratamento de superfície Implantes de titânio Bioactive coating Peri-implantitis Surface treatment Titanium implants