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Publication
Proteína C reativa e doença cardiovascular
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_23829 | 3.15 MB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
As doenças cardiovasculares (DCV) são responsáveis por uma elevada taxa de
mortalidade na sociedade portuguesa. Uma das causas mais comuns das DCV é a
inflamação vascular que se associa à patogénese da aterosclerose. Como forma de auxiliar
a deteção das DCV e acompanhar a sua evolução, são utilizados os biomarcadores
inflamatórios, que constituem uma ferramenta valiosa na avaliação do prognóstico da
patologia e na terapêutica a implementar.
A proteína C reativa (PCR) é uma proteína de fase aguda (PFA), produzida
essencialmente no fígado, pelos hepatócitos, após estimulação pelas citocinas proinflamatórias.
A PCR é considerada um marcador significativo da reação inflamatória,
cuja concentração não é afetada pela dieta ou variações circadianas. Esta PFA é também
apontada como um importante mediador do processo de desenvolvimento da
aterosclerose. A sua concentração é quantificada por métodos de alta sensibilidade (PCRas).
Estes procedimentos possibilitam a identificação e diagnóstico de indivíduos com maior
risco de adquirir problemas cardiovasculares, bem como o acompanhamento e a
terapêutica associada à situação clínica de cada doente portador de DCV.
Cardiovascular diseases (CVD) are responsible for a high rate of mortality in Portuguese society. One of the most common causes of CVD is vascular inflammation which is associated to the pathogenesis of atherosclerosis. As a way to assist the detection of CVD and monitor its evolution, are used inflammatory biomarkers, which constitute a valuable tool in evaluating the prognosis of pathology and therapy implement. The C-reactive protein (CRP) is an acute phase protein (APP), produced mainly in the liver by hepatocytes, after stimulation by cytokines pro-inflammatory. CRP is considered a significant marker of inflammatory reaction, since it is not affected by diet or circadian variations. This APP is also pointed as an important mediator of the atherosclerosis development. Its concentrations can be quantified by high sensitivity methods (hs-CRP). These procedures enable the identification and diagnosis of individuals with increased risk of acquiring cardiovascular problems, as well as monitoring and therapy associated with clinical situation of each patient bearer of CVD.
Cardiovascular diseases (CVD) are responsible for a high rate of mortality in Portuguese society. One of the most common causes of CVD is vascular inflammation which is associated to the pathogenesis of atherosclerosis. As a way to assist the detection of CVD and monitor its evolution, are used inflammatory biomarkers, which constitute a valuable tool in evaluating the prognosis of pathology and therapy implement. The C-reactive protein (CRP) is an acute phase protein (APP), produced mainly in the liver by hepatocytes, after stimulation by cytokines pro-inflammatory. CRP is considered a significant marker of inflammatory reaction, since it is not affected by diet or circadian variations. This APP is also pointed as an important mediator of the atherosclerosis development. Its concentrations can be quantified by high sensitivity methods (hs-CRP). These procedures enable the identification and diagnosis of individuals with increased risk of acquiring cardiovascular problems, as well as monitoring and therapy associated with clinical situation of each patient bearer of CVD.
Description
Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas
Keywords
Proteína C reativa Doença cardiovascular Inflamação Biomarcador cardíaco Biomarcador Inflamatório Aterosclerose Fatores de risco Prevenção C-reactive protein Cardiovascular disease Inflammation Cardiac biomarker Inflammatory biomarker Atherosclerosis Risk factors Prevention