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Characterization and biocompatibility evaluation of cutaneous formulations containing lipid nanoparticles

2017Journal article Restricted access
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dc.contributor.authorEiras, F.
dc.contributor.authorAmaral, M.H.
dc.contributor.authorSilva, R.
dc.contributor.authorMartins, E.
dc.contributor.authorLobo, J.M. Sousa
dc.contributor.authorSilva, Ana Catarina
dc.date.accessioned2021-04-27T10:33:47Z
dc.date.available2021-04-27T10:33:47Z
dc.date.issued2017
dc.description.abstractNanostructured lipid carriers (NLC) are well-known systems that show effectiveness to improve skin hydration, being suggested for cosmetic and dermatological use. Nonetheless, NLC dispersions present low viscosity, which is non-attractive for cutaneous application. To circumvent this drawback, the dispersions can be gelled or incorporated in semisolid systems, increasing the final formulation consistency. In this study, we prepared a hydrogel based on NLC containing vitamin E (HG-NLCVE) and evaluated its suitability for cutaneous application. The experiments started with the HG-NLCVE characterization (organoleptic analysis, accelerated stability, particle size, morphology, pH, texture and rheology). Afterwards, in vitro experiments were carried out, evaluating the formulation biocompatibility (MTT and Neutral Red) and irritant potential (Hen's egg test on the chorioallantoic membrane, HET-CAM) for cutaneous application. The results showed that the HG-NLCVE has adequate features for skin application, is biocompatible and non-irritant. From this study, it was predicted the in vivo irritant potential of the developed formulation, avoiding the need to perform a high number of tests on human volunteers. Regarding vitamin E and NLC potential to improve skin hydration, we suggest that the HG-NLCVE could be used in cosmetic (e.g. moisturizers and anti-aging) or dermatologic (e.g. xerosis and other skin disorders) products.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ijpharm.2017.01.045pt_PT
dc.identifier.issn0378-5173
dc.identifier.urihttp://hdl.handle.net/10284/9799
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectNanostructured lipid carrierspt_PT
dc.subjectVitamin Ept_PT
dc.subjectCutaneous applicationpt_PT
dc.subjectHydrogelpt_PT
dc.subjectBiocompatibilitypt_PT
dc.subjectIrritant potentialpt_PT
dc.titleCharacterization and biocompatibility evaluation of cutaneous formulations containing lipid nanoparticlespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage380pt_PT
oaire.citation.issue1-2pt_PT
oaire.citation.startPage373pt_PT
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume519pt_PT
person.familyNameSilva
person.givenNameAna Catarina
person.identifier953153
person.identifier.ciencia-id5C1D-ED22-0D64
person.identifier.orcid0000-0001-6923-0232
person.identifier.ridF-1875-2017
person.identifier.scopus-author-id57028697500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67e7f707-32ec-444a-a20d-a17f8e6e7c21
relation.isAuthorOfPublication.latestForDiscovery67e7f707-32ec-444a-a20d-a17f8e6e7c21

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