Repository logo
 
Publication

Contribution of oxidative metabolism to cocaine-induced liver and kidney damage

2012Journal article Restricted access
Simple item page
dc.contributor.authorValente, M.J.
dc.contributor.authorCarvalho, F.
dc.contributor.authorBastos, M.d.L.
dc.contributor.authorde Pinho, P.G.
dc.contributor.authorCarvalho, Márcia
dc.date.accessioned2021-07-02T16:23:11Z
dc.date.available2021-07-02T16:23:11Z
dc.date.issued2012
dc.description.abstractCocaine is a potent psychoactive illicit substance and its abuse represents a major health burden worldwide. The pharmacodynamics and toxicity of cocaine have been extensively documented, and are generally associated to its affinity towards neurotransmitters transporters and several receptors. However, drug-related formation of reactive compounds, as is the case of pro-oxidant reactive species, and interaction at molecular level is still an understudied matter. The involvement of oxidative stress (OS) in cocaine-induced toxicity has been reported in both human and animal models, in several organs and systems, including heart, liver, kidney, and central nervous system (CNS). Cytochrome P450 (CYP450)-mediated cocaine metabolism yields the reactive pro-oxidant compound norcocaine (NCOC) and further oxidative metabolites. Special emphasis should be given to the stable radical norcocaine nitroxide (NCOC-NO·), which plays a key role in cocaine-induced hepatotoxicity, either by entering a futile redox cycle with an N-oxidative metabolite, or by being further oxidized to a highly reactive ion. In fact, cocaine-induced generation of reactive oxygen species (ROS) and consequent OS has been postulated based on the reactivity of cocaine N-oxidative metabolites. Depletion of cellular antioxidant defenses and impairment of mitochondrial respiration have also been considered important causes of ROS production, and subsequent cell death mediated by cocaine. The present review provides a thorough description of the current knowledge on cocaine oxidative metabolism and its role on drug-induced liver and kidney damage.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2174/092986712803988938pt_PT
dc.identifier.eissn1875-533X
dc.identifier.issn0929-8673
dc.identifier.urihttp://hdl.handle.net/10284/10041
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBentham Science Publisherspt_PT
dc.relationPEst-C/EQB/LA0006/201pt_PT
dc.subjectCocainept_PT
dc.subjectMetabolismpt_PT
dc.subjectOxidative stresspt_PT
dc.subjectLiverpt_PT
dc.subjectKidneypt_PT
dc.subjectToxicitypt_PT
dc.titleContribution of oxidative metabolism to cocaine-induced liver and kidney damagept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage5606pt_PT
oaire.citation.issue33pt_PT
oaire.citation.startPage5601pt_PT
oaire.citation.titleCurrent Medicinal Chemistrypt_PT
oaire.citation.volume19pt_PT
person.familyNameCarvalho
person.givenNameMarcia
person.identifier2017111
person.identifier.ciencia-id8B10-171E-E63E
person.identifier.orcid0000-0001-9884-4751
person.identifier.ridD-5999-2013
person.identifier.scopus-author-id7201413997
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3837b828-ba57-47f7-a811-cce65e4922c6
relation.isAuthorOfPublication.latestForDiscovery3837b828-ba57-47f7-a811-cce65e4922c6

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Contribution of oxidative metabolism to cocaine-induced liver and kidney damage.pdf
Size:
1.08 MB
Format:
Adobe Portable Document Format
Download

Collections

FCS - Artigos em Revistas Científicas Internacionais com Arbitragem Científica