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Uso dos canabinóides no tratamento da dor orofacial: revisão sistemática
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Abstract(s)
Objetivo: Dor orofacial define-se como dor e disfunção que afeta a transmissão motora e/ou sensorial do sistema trigeminal. As causas são multifatoriais e os tratamentos multidisciplinares. Os canabinóides, compostos químicos encontrados na planta canábis, têm demonstrado interesse terapêutico pelo efeito analgésico, anti-inflamatório, relaxante muscular, antioxidante, antiemético e antiespasmódico. O objetivo desta revisão sistemática foi avaliar quais os canabinóides que têm potencial terapêutico benéfico no tratamento e prevenção da dor orofacial.
Métodos: Três observadores, realizaram uma revisão sistemática, de estudos clínicos de coorte, caso-controlo e experimentais, que abordaram o uso dos canábinóides no tratamento da dor orofacial, em adultos. As bases de dados utilizadas foram: Medline, EBSCO, Web of Science, LILACS, Gale in Context: Science, Scopus, Science Citation Index Expanded e Suplemental Index e as palavras-chave “orofacial pain” e “cannab*” nas suas diferentes designações Medical Subject Headings combinadas com diferentes operadores boleanos.
Resultados: Da pesquisa direta resultaram 161 artigos e foram obtidos 51 artigos por referências cruzadas, o que resultou em 212 artigos para leitura do resumo e 10 artigos foram selecionados para leitura integral. Após a aplicação dos critérios de inclusão e exclusão, com a concordância excelente dos três observadores, foram aceites 6 artigos para inclusão.
Conclusões: Canabinóides mostraram ser eficazes no tratamento de alguns tipos de dores orofaciais, como a neuropática e a dor músculo-esquelética. Na dor aguda de origem dentoalveolar os canabinóides não demonstraram potencial terapêutico. Mais estudos serão necessários para sistematizar a utilização dos canabinóides na área da dor orofacial, nomeadamente, na dor neuropática e músculo-esquelética.
Objective: Orofacial pain is defined as pain and dysfunction affecting the motor and/or sensory transmission of the trigeminal system. The causes are multifactorial and the treatments are multidisciplinary. Cannabinoids, chemical compounds found in the cannabis plant, have shown therapeutic interest for their analgesic, anti-inflammatory, muscle relaxant, antioxidant, antiemetic and antispasmodic effects. The aim of this systematic review was to evaluate which cannabinoids have beneficial therapeutic potential in the treatment and prevention of orofacial pain. Methods: Three observers conducted a systematic review of cohort, case- control and experimental clinical studies addressing the use of cannabinoids in the treatment of orofacial pain in adults. The databases used were: Medline, EBSCO, Web of Science, LILACS, Gale in Context: Science, Scopus, Science Citation Index Expanded and Suplemental Index and the key-words “orofacial pain” and “cannab*” in their differents Medical Subject Headings combined with differents boolean operators. Results: The direct search resulted in 161 articles and 51 articles were obtained by cross- referencing, which resulted in 212 articles for abstract reading and 10 articles were selected for full reading. After applying the inclusion and exclusion criteria, with excellent agreement from all three observers, 6 articles were accepted for inclusion. Conclusions: Cannabinoids have been shown to be effective in treating some types of orofacial pain, such as neuropathic and musculoskeletal pain. In acute pain of dentoalveolar origin, cannabinoids did not show therapeutic potential. Further studies are needed to systematise the use of cannabinoids in the area of orofacial pain, particularly neuropathic and musculoskeletal pain.
Objective: Orofacial pain is defined as pain and dysfunction affecting the motor and/or sensory transmission of the trigeminal system. The causes are multifactorial and the treatments are multidisciplinary. Cannabinoids, chemical compounds found in the cannabis plant, have shown therapeutic interest for their analgesic, anti-inflammatory, muscle relaxant, antioxidant, antiemetic and antispasmodic effects. The aim of this systematic review was to evaluate which cannabinoids have beneficial therapeutic potential in the treatment and prevention of orofacial pain. Methods: Three observers conducted a systematic review of cohort, case- control and experimental clinical studies addressing the use of cannabinoids in the treatment of orofacial pain in adults. The databases used were: Medline, EBSCO, Web of Science, LILACS, Gale in Context: Science, Scopus, Science Citation Index Expanded and Suplemental Index and the key-words “orofacial pain” and “cannab*” in their differents Medical Subject Headings combined with differents boolean operators. Results: The direct search resulted in 161 articles and 51 articles were obtained by cross- referencing, which resulted in 212 articles for abstract reading and 10 articles were selected for full reading. After applying the inclusion and exclusion criteria, with excellent agreement from all three observers, 6 articles were accepted for inclusion. Conclusions: Cannabinoids have been shown to be effective in treating some types of orofacial pain, such as neuropathic and musculoskeletal pain. In acute pain of dentoalveolar origin, cannabinoids did not show therapeutic potential. Further studies are needed to systematise the use of cannabinoids in the area of orofacial pain, particularly neuropathic and musculoskeletal pain.
Description
Keywords
Dor orofacial Tratamento Canábis Canabinóides Adultos Orofacial pain Treatment Cannabis Cannabinoids Adults