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Publication
Efeitos do cádmio e chumbo na saúde humana
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_21501 | 1.09 MB | Adobe PDF |
Advisor(s)
Abstract(s)
A corrente aplicação industrial do cádmio e chumbo afetam a saúde humana através da sua exposição ocupacional e ambiental. A sua interferência na atividade celular normal por recurso a diversos mecanismos conjuntos e intrínsecos a cada metal e a sua fraca eliminação e consequente bioacumulação são responsáveis pelos efeitos tóxicos em diversos órgãos incluindo rim, fígado, pulmão e sistema nervoso. A exposição ao cádmio está associada ao aparecimento de osteoporose, doenças cardiovasculares, cálculos renais, abortos espontâneos e partos prematuros, infertilidade e parece estar relacionada com o desenvolvimento de doenças neurodegenerativas tais como Alzheimer, Parkinson e Huntington. O chumbo está relacionado com o desenvolvimento de anemia, por perturbação na biossíntese do grupo heme, osteoporose, colesterol elevado, cólica saturnina, problemas do foro psiquiátrico e doenças neurodegenerativas, aparecimento da placa aterosclerótica com as doenças cardiovasculares associadas. A Agência Internacional de Investigação do Cancro classificou estes metais como possíveis carcinogénicos humanos. A destoxificação com recurso a agentes quelantes e suplementação antioxidante fazem parte do protocolo atual com benefícios terapêuticos demonstrados. A monitorização das exposições e identificação das fontes de contaminação com a adoção de estratégias de prevenção são medidas para a diminuição do risco que estas acarretam.
The current industrial application of cadmium and lead affect human health through its occupational and environmental exposure. Their interference in normal cell activity using a variety of intrinsic mechanisms to each metal and their weak removal and subsequent bioaccumulation are responsible for toxics effects in various organs including kidney, liver, lungs and nervous system. Cadmium is associated with the development of osteoporosis, cardiovascular diseases, kidney stones, miscarriages and premature births, infertility and seems to be related to the onset of Alzheimer's, Parkinson's and Huntington's. Lead is related with the development of anemia, disturbance in the heme’s biosynthesis, osteoporosis, high cholesterol levels, saturnine colic, psychiatric problems and neurodegenerative diseases, the appearance of atherosclerosis and associated cardiovascular diseases. The International Agency for Research on Cancer has classified these metals as potential human carcinogens. The detoxification using the chelating and antioxidant supplementation are part of the current protocol with proven therapeutic benefits. Currently, the monitoring of exposure and identification of contamination sources by adopting preventive strategies are measures taken to reduce the risk that these entail.
The current industrial application of cadmium and lead affect human health through its occupational and environmental exposure. Their interference in normal cell activity using a variety of intrinsic mechanisms to each metal and their weak removal and subsequent bioaccumulation are responsible for toxics effects in various organs including kidney, liver, lungs and nervous system. Cadmium is associated with the development of osteoporosis, cardiovascular diseases, kidney stones, miscarriages and premature births, infertility and seems to be related to the onset of Alzheimer's, Parkinson's and Huntington's. Lead is related with the development of anemia, disturbance in the heme’s biosynthesis, osteoporosis, high cholesterol levels, saturnine colic, psychiatric problems and neurodegenerative diseases, the appearance of atherosclerosis and associated cardiovascular diseases. The International Agency for Research on Cancer has classified these metals as potential human carcinogens. The detoxification using the chelating and antioxidant supplementation are part of the current protocol with proven therapeutic benefits. Currently, the monitoring of exposure and identification of contamination sources by adopting preventive strategies are measures taken to reduce the risk that these entail.