Percorrer por autor "Sauger, Manon Marie"
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- The contribution of the new cellular technologies to periodontal tissue regeneration: advances and therapeutic perspectives – narrative reviewPublication . Sauger, Manon Marie; Ribeiro, Maria GilIntroduction: Oral and periodontal diseases remain a major global health problem, often leading to the loss of tooth-supporting structures and functional deterioration. Traditional approaches to managing these conditions have largely focused on mechanical repair and replacement, with limited capacity for true biological regeneration. However, advances in stem cell biology, nanotechnology, gene editing, and acellular therapeutic strategies have opened up new possibilities in periodontal tissue regeneration. This narrative review explores the landscape of emerging cellular technologies, cell-free therapies, gene editing, and tissue engineering, and evaluates their applications, limitations, and clinical perspectives in regenerative dentistry. Objective: This work is expected to contribute to identifying, analysing, and comparing the impact of these new technologies on periodontal tissue reconstruction and regeneration. Special attention is given to stem cell-based therapies, gene editing tools, nanotechnologies, and exosome-mediated approaches, with the aim of understanding their current status, translational potential, and challenges in clinical implementation. Methodology: This narrative review was based on a qualitative selection of scientific literature from 2015 to 2025. A comprehensive search was conducted using databases such as PubMed and ScienceDirect. Studies were selected based on relevance, innovation, clarity of experimental design, and potential clinical application. To develop this work, more than 107 articles were critically analysed for convergence, divergence, and thematic relevance. Results: The analysis identified several promising technological avenues in periodontal regeneration. Mesenchymal stem cells support osteogenic and immunomodulatory processes but are limited by donor variability and inconsistent in vivo results. Induced pluripotent stem cells offer greater plasticity and specificity, with the ability to form dental tissues, although safety and differentiation challenges remain. Exosomes offer a cell-free regenerative strategy, modulating key pathways such as PI3K/Akt and Wnt/β-catenin, but their variability complicates clinical standardisation. CRISPR-Cas9 technologies enable precise gene targeting in inflammatory and developmental conditions, but ethical and technical barriers persist. Finally, nanomaterials such as silver nanoparticles, silicon nanowires, and graphene composites show strong potential to improve tissue healing through bioactivity and antimicrobial properties. Conclusion: Innovations in stem cells, extracellular vesicles such as exosomes, gene editing, and biomaterials currently represent additional tools for more precisely guiding tissue regeneration. While these approaches show great promise, they are still in an early stage of development, requiring further study before their application in routine clinical practice. The goal is no longer simply to rebuild lost structures, but to encourage the body to repair itself more naturally and functionally, a direction that appears increasingly plausible with continued research and collaboration.