Browsing by Author "Real Oliveira, Maria Elisabete"
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- Chapter 3 - General aspects of multifunctional nanosystemPublication . Lúcio, Marlene; Real Oliveira, Maria Elisabete; Lopes, Carla Martins
- Chapter 4 - Organic nanocarriers for brain drug deliveryPublication . Lúcio, Marlene; Lopes, Carla Martins; Fernandes, Eduarda; Gonçalves, Hugo; Real Oliveira, Maria ElisabeteAlthough the blood–brain barrier remains a major barrier to drug delivery, organic nanocarriers (ONCs) have been demonstrated to be effective in targeting and delivering therapeutic agents to the brain and have provided promising preclinical outcomes. Because of their favourable physicochemical properties, such as biocompatible composition, nanometric dimensions, large surface area compared to volume and easily tuneable surfaces, ONCs have proven to be excellent transport vehicles capable of prolonging drug (or other therapeutic agents) circulation time and of addressing the challenges posed by numerous diseases affecting the brain.This chapter presents an overview of the different types of ONCs for brain delivery, including a description of their advantages and disadvantages, and a set of preclinical studies illustrating the most effective strategies for effective brain distribution. Biodegradation and bioelimination issues and future challenges for effective clinical translation are also addressed.
- Chapter 5 - Lipid-based nanocarriers for co-delivery of anticancer drugs and natural compoundsPublication . Fernandes, Eduarda; Soares, Telma; Lopes, Carla Martins; Real Oliveira, Maria Elisabete; Lúcio, Marlene
- Development of lipid-based colloidal nanocarriers for topical application of acyclovirPublication . Silva, Juliana; Lopes, Carla Martins; Catita, José; Real Oliveira, Maria Elisabete; Lúcio, Marlene
- Diclofenac’s toxicity revisited with biomimetic models and biophysical studiesPublication . Lúcio, Marlene; Lopes, Carla Martins; Fernandes, Eduarda; Soares, Telma; Real Oliveira, Maria Elisabete
- Diclofenac: topical gastrointestinal damage revisited with biomimetic models and biophysical studiesPublication . Lúcio, Marlene; Lopes, Carla Martins; Fernandes, Eduarda; Soares, Telma; Real Oliveira, Maria Elisabete
- Functional lipid nanosystems in cancerPublication . Lúcio, Marlene; Lopes, Carla Martins; Real Oliveira, Maria ElisabeteCancer remains one of the most challenging issues in modern medicine, being responsible for a high number of deaths every year. Recent important developments in cancer diagnosis and therapy based on the versatility of nanosystems have made it possible to incorporate multifunctional synergistic actions into a single delivery system. This book compiles the research on the use of functional lipid nanosystems that combine different strategies in one single nanosystem to enhance overall cancer treatment. Besides providing an overview of the current functional nanosystem strategies, it also offers researchers essential theoretical background on cancer, the physiological barriers to its treatment, aspects related to the design and optimization of nanocarriers for cancer treatment, and clinical developments, including promises, safety issues, and the expected future. The editors bring together a group of scientists from all over the world to discuss the most relevant issues and to provide updates on functional lipid nanosystems and cancer.
- Lipid colloidal dispersions loaded with omega 3 fatty acids and/or resveratrol developed for topical application against psoriasisPublication . Caldas, Ana Rita; Real Oliveira, Maria Elisabete; Lopes, Carla Martins; Lúcio, Marlene
- Pre-formulation studies for rational development of lipid colloidal carriers containing resveratrolPublication . Caldas, Ana Rita; Real Oliveira, Maria Elisabete; Lopes, Carla Martins; Lúcio, Marlene
- The versatility of membrane-water partitioning in pharmacokinetic modellingPublication . Fernandes, Eduarda; Soares, Telma; Almeida, A.; Benfeito, S.; Lopes, Carla Martins; Sarmento, Bruno; Borges, Fernanda; Real Oliveira, Maria Elisabete; Lúcio, Marlene