Browsing by Author "Pereira, Gisela de Souza"
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- Sepsis as a result of odontogenic infections: is there a reason for concern? A narrative reviewPublication . Pereira, Gisela de Souza; Reis, TiagoDentistry has faced significant challenges with the rise of the "Focal Infection Era," which led to the widespread practice of tooth extraction and impeded the advancement of endodontics due to the belief that bacteria and toxins in dentinal tubules could cause systemic diseases. Although this theory has since been refuted, contemporary research has re-evaluated the relationship between apical periodontitis, endodontic treatment, and systemic health, investigating whether endodontic diseases could impact overall health. Studies have shown that common oral diseases, such as caries and periodontitis, caused by bacteria present in the oral cavity, can lead to bacteraemia during dental procedures or due to poor oral hygiene. This has prompted investigations into the associations between apical periodontitis and systemic conditions, such as cardiovascular diseases, diabetes, adverse pregnancy outcomes, and autoimmune diseases. Evidence suggests that bacteraemia and low-grade systemic inflammation related to apical periodontitis may negatively affect systemic health. Furthermore, the literature highlights an increase in systemic infections originating from odontogenic sources, possibly due to improved detection methods or delayed interventions. This review concludes that untreated conditions can rapidly spread through the bloodstream, leading to severe infections that require intensive care. Despite medical advancements, these infections continue to represent a significant risk, especially for immunocompromised individuals, potentially resulting in sepsis and increased mortality. Often originating from preventable issues such as dental caries, these infections underscore the urgent need for more effective public health measures to mitigate their impact.