Percorrer por autor "Guez, Jenna"
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- Biomarkers related to pulpal diseases in diabetic and in healthy patients: integrative reviewPublication . Guez, Jenna; Kato, Gabriel Fukunaga; Guimarães, DuarteIntroduction: Diabetes mellitus is a chronic metabolic disease characterized by persistent hyperglycemia and systemic inflammatory alterations that may affect multiple tissues, including the dental pulp. Increasing evidence suggests that systemic metabolic dysregulation may influence pulpal inflammation and tissue responses. Inflammatory biomarkers such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and matrix metalloproteinase-9 (MMP-9) have been associated with the progression of pulpal inflammation. Additionally, hyperglycemia may promote the accumulation of advanced glycation end-products (AGEs) and activation of the AGE-RAGE signaling pathway, contributing to oxidative stress and structural alterations in pulpal tissues. This integrative review aimed to analyze the available scientific evidence regarding inflammatory biomarkers in dental pulp and their relationship with systemic metabolic alterations associated with type 2 diabetes mellitus. Methodology: An integrative literature review was conducted using PubMed, Web of Science, and Embase databases. Original experimental and clinical studies, including in vitro, animal and clinical studies investigating inflammatory biomarkers in dental pulp from diabetic and non-diabetic patients were considered for inclusion. Study selection resulted in the inclusion of six studies for qualitative synthesis. Results: The analyzed studies consistently demonstrated the involvement of inflammatory biomarkers such as IL-6, TNF-α, and MMP-9 in pulpal inflammation. Several studies reported increased expression of these biomarkers in diabetic conditions compared with non-diabetic individuals. Experimental and animal studies further indicated that chronic hyperglycemia and AGE-RAGE pathway activation may promote oxidative stress, vascular alterations and intrapulpal calcification. Conclusion: Current evidence suggests that type 2 diabetes mellitus may influence pulpal inflammation and structural alterations through metabolic and inflammatory mechanisms. Inflammatory biomarkers such as IL-6, TNF-α, and MMP-9 may play an important role in reflecting the severity of pulpal inflammation.