Percorrer por autor "Doktorovova, Slavomira"
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- Lipid nanoparticle mediated drug delivery for safer cancer treatment: example of paclitaxelPublication . Doktorovova, Slavomira; Lopes, Carla Martins; Souto, Eliana B.Os vectores coloidais de natureza lipídica têm atraído particular atenção para o desenvolvimento de terapias mais seguras e eficazes aplicadas a várias doenças. As vantagens da utilização das nanopartículas lipídicas são exemplificadas utilizando o paclitaxel, um anticancerígeno particularmente interessante para o desenvolvimento de novas formas farmacêuticas mais adequadas para o tratamento do cancro. De facto, este fármaco apresenta problemas de insolubilidade aquosa e sérios efeitos secundários concomitantes à administração da forma farmacêutica convencional (Taxol). Este artigo apresenta uma revisão das razões para a reformulação do paclitaxel e sumariza as vantagens de novas formas farmacêuticas contendo nanopartículas lipídicas para a administração deste anticancerígeno. Colloidal carriers composed of lipids attract much attention in the development of safer and more effective therapy of various diseases. The advantages of lipid-based nanoparticles are illustrated on the example of paclitaxel, a challenging chemotherapeutic drug for the development of a novel and more suitable dosage form for cancer treatment. Paclitaxel is known for its water insolubility and serious side effects when administered by its conventional formulation (Taxol). This paper reviews the reasons of further re-formulation of Paclitaxel and summarizes the achievements of lipid nanoparticle-based formulations of this drug.
- Novel carriers for sunscreen formulationsPublication . Doktorovova, Slavomira; Marques, Cecília; Barbosa, Catarina; Lopes, Carla Martins; Souto, Eliana B.Sunscreens are cosmetic products for convenient and safe delivery of solar filters. These are used to prevent the skin damage caused by sunlight exposure. Due to photo-instability and potential adverse effects of some of these filters, novel application forms are demanded. Lipid based colloidal carriers commonly named as lipospheres provide the advantage of sufficient protection of the solar filters, their delivery to upper skin layer only, and controlled release. Being composed of biocompatible and biodegradable materials similar to those existing in the stratum corneum, they are generally well tolerated. This review gives an overview of novel approaches to sunscreen formulations.
- The role of lipids in drug absorption throught the GITPublication . Doktorovova, Slavomira; Morsy, Tarek; Balcão, Victor; Souto, Eliana B.Os vectores lipídicos apresentam inúmeras vantagens para a administração oral de substâncias farmacológicas, p.ex. são compostos por moléculas lipídicas semelhantes àquelas que figuram nos tecidos humanos, tornando-se biocompatíveis, biotoleráveis e biodegradáveis. São exemplos as tradicionais emulsões O/A, as suspensões de nanopartículas lipídicas (SLNs e NLC s) e, recentemente, as SolEmuls®, que permitem localizar fármacos fracamente solúveis em ambas as fases das emulsões, na camada interfacial de lecitina. Este artigo aborda o papel dos lípidos no aumento da absorção e da biodisponibilidade de fármacos administrados oralmente. Lipid carriers show several advantages for oral delivery of pharmacologically active drugs, e.g. are composed of lipid molecules similar to those in human tissues, becoming therefore biocompatible, biotolerable and biodegradable. Examples include traditional o/w emulsions, suspensions of lipid nanoparticles (SLNs and NLC s) and, recently, the SolEmuls®, which allows localizing poorly soluble drug molecules both in oil and aqueous phases, in the interfacial layer of lecithin. This paper reports on the role of lipids in enhancing both drug absorption and bioavailability when administered orally.