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Mycobacterium avium spp. paratuberculosis up-regulates CD40 expression and down-regulates IL-10 production by human macrophages

2009Journal article Open access
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dc.contributor.authorCampos, Nair
dc.contributor.authorCastro, Ana Rita
dc.contributor.authorCabral, Joanapor
dc.contributor.authorBacalhau, Nicole Marquespor
dc.contributor.authorMagro, Fernando
dc.contributor.authorSarmento, Amélia
dc.date.accessioned2010-02-23T14:19:16Zpor
dc.date.accessioned2011-10-06T14:52:45Z
dc.date.available2010-02-23T14:19:16Zpor
dc.date.available2011-10-06T14:52:45Z
dc.date.issued2009por
dc.description.abstractMycobacterium avium spp paratuberculosis (MAP) tem vindo a ser sugerido como um agente etiológico da doença de Crohn. Este estudo teve por objectivo avaliar os efeitos imunomoduladores do MAP em macrófagos humanos. Os macrófagos foram obtidos a partir do sangue de controlos normais ou pacientes com doença de Crohn, e infectados in vitro com MAP ou Mycobacterium avium spp. avium (MA). Os efeitos observados na produção de IL-10 e expressão de CD40 sugerem que a infecção micobacteriana pode contribuir para a imunopatologia observada na doença de Crohn. Mycobacterium avium spp paratuberculosis (MAP) has been suggested as one etiologic agent of Crohn’s disease. In this study, we aimed to evaluate immunomodulating effects of MAP on human macrophages. Macrophages were obtained from the blood of normal controls or Crohn’s patients, and were infected in vitro with MAP or Mycobacterium avium spp. avium (MA). The effects observed on IL-10 production and CD40 expression, point to a role of mycobacteria in the pathology of Crohn’s disease.por
dc.identifier.citationRevista da Faculdade de Ciências da Saúde. Porto. ISSN 1646-0480. 6 (2009) 22-30.por
dc.identifier.issn1646-0480por
dc.identifier.urihttp://hdl.handle.net/10284/1266por
dc.language.isoengpor
dc.relation.ispartofseriesRevista da Faculdade de Ciências da Saúdepor
dc.relation.ispartofseries6por
dc.subjectDoença de Crohnpor
dc.subjectMacrófagospor
dc.subjectMycobacterium avium spp paratuberculosispor
dc.subjectCrohn’s diseasepor
dc.subjectMacrophagespor
dc.titleMycobacterium avium spp. paratuberculosis up-regulates CD40 expression and down-regulates IL-10 production by human macrophagespor
dc.typejournal article
dspace.entity.typePublication
person.familyNameNazareth Campos
person.familyNameCastro
person.familyNameMagro
person.familyNameSarmento
person.givenNameNair
person.givenNameAna Rita
person.givenNameFernando
person.givenNameAmélia
person.identifier118915
person.identifier.ciencia-idCA17-881A-868F
person.identifier.ciencia-idC616-293B-A303
person.identifier.ciencia-id1A1F-EB62-2AF9
person.identifier.orcid0000-0001-6297-4773
person.identifier.orcid0000-0003-0524-156X
person.identifier.orcid0000-0003-2634-9668
person.identifier.orcid0000-0001-5137-8474
person.identifier.ridN-2547-2013
person.identifier.scopus-author-id55932136100
person.identifier.scopus-author-id55901273800
person.identifier.scopus-author-id7007082944
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication7b2e3d47-0650-47de-975d-77840654c958
relation.isAuthorOfPublicationdee158e2-7b58-4f81-a63e-554ead9602e6
relation.isAuthorOfPublication18933263-0f0f-49b9-9e3a-bb61719e38e8
relation.isAuthorOfPublication5593cdec-ca85-4f05-b4f2-97193accaaab
relation.isAuthorOfPublication.latestForDiscoverydee158e2-7b58-4f81-a63e-554ead9602e6

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FCS - Número 06 (2009)