Repository logo
 
Publication

Cytokines and growth factors

dc.contributor.authorSilva, Ana Catarina
dc.contributor.authorLobo, J. M. Sousa
dc.date.accessioned2021-04-27T16:00:51Z
dc.date.available2021-04-27T16:00:51Z
dc.date.issued2019
dc.description.abstractSeveral cytokines have been used to treat autoimmune diseases, viral infections, and cancer and to regenerate the skin. In particular, interferons (INFs) have been used to treat cancer, hepatitis B and C, and multiple sclerosis, while interleukins (ILs) and tumor necrosis factors (TNFs) have been used in the management of different types of cancer. Concerning the hematopoietic growth factors (HGFs), epoetin has been used for anemia, whereas the colony-stimulating factors (CSFs) have been used for neutropenia. Other growth factors have been extensively explored, although most still need to demonstrate in vivo clinical relevance before reaching the market.This chapter provides an overview on the therapeutic applications of biological medicines containing recombinant cytokines and growth factors (HGFs and others). From this review, we concluded that the clinical relevance of recombinant cytokines has been increasing. Since the 1980s, the European Medicines Agency (EMA) and/or Food and Drug Administration (FDA) have approved 89 biological medicines containing recombinant cytokines. Among these, 18 were withdrawn, 24 are biosimilars, and 18 are orphans.So far, considerable progress has been made in discovering new cytokines, additional cytokine functions, and how they interfere with human diseases. Future prospects include the approval of more biological and biosimilar medicines for different therapeutic applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/10_2019_105pt_PT
dc.identifier.isbn978-3-030-40464-2
dc.identifier.urihttp://hdl.handle.net/10284/9806
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectCytokinespt_PT
dc.subjectGrowth factorspt_PT
dc.subjectHematopoietic growth factorspt_PT
dc.subjectInterferonspt_PT
dc.subjectInterleukinspt_PT
dc.subjectTumor necrosis factorspt_PT
dc.titleCytokines and growth factorspt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage113pt_PT
oaire.citation.startPage87pt_PT
oaire.citation.titleAdvances in biochemical engineering/biotechnologypt_PT
oaire.citation.volume171pt_PT
person.familyNameSilva
person.givenNameAna Catarina
person.identifier953153
person.identifier.ciencia-id5C1D-ED22-0D64
person.identifier.orcid0000-0001-6923-0232
person.identifier.ridF-1875-2017
person.identifier.scopus-author-id57028697500
rcaap.rightsclosedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublication67e7f707-32ec-444a-a20d-a17f8e6e7c21
relation.isAuthorOfPublication.latestForDiscovery67e7f707-32ec-444a-a20d-a17f8e6e7c21

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Chap. 4_Cytokines and Growth Factors.pdf
Size:
444.86 KB
Format:
Adobe Portable Document Format