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Publication
Periodontite apical e desordens sistémicas: doença cardiovascular
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPP_40058 | 608.79 KB | Adobe PDF |
Advisor(s)
Abstract(s)
A Periodontite Apical (AP) representa um infeção de origem endodôntica que leva a
um estado inflamatório. Inflamações crónicas, quando em nível sistémico, podem despoletar
diversas doenças. Mediadores inflamatórios são conhecidos por levar a disfunção endotelial
(ED) e por desempenhar um papel chave na iniciação e progressão da aterosclerose, a principal
causa de doença coronária cardíaca (CHD). Portanto, inflamações dentárias crónicas, como a
AP, poderiam fornecer um ambiente propício para eventos cardiovasculares (CVEs).
Há sugestões de que AP e doenças cardiovasculares (CVDs) compartilhem
patogénese e atores moleculares similares. As APs são comuns na população em geral e
poderiam perpetuar a inflamação sistémica e, em troca, contribuir para o aumento da incidência
de CVD. Há uma escassez de pesquisas existentes a respeito das consequências da doença
endodôntica na saúde sistémica. Até o momento, poucos estudos têm investigado uma potencial
correlação entre AP e CVD, e seus achados são inconclusivos.
Apical Periodontitis (AP) represents an infection of endodontic origin that leads to an inflammatory state. Chronic inflammations, when at the systemic level, can trigger several diseases. Inflammatory mediators are known to lead to endothelial dysfunction (ED) and to play a key role in the initiation and progression of atherosclerosis, the main cause of coronary heart disease (CHD). Therefore, chronic dental inflammation, such as AP could provide an environment conducive to cardiovascular events (CVEs). There are suggestions that AP and cardiovascular diseases (CVDs) share similar pathogenesis and molecular actors. APs are common in the general population and could perpetuate systemic inflammation and, in turn, contribute to the increased incidence of CVD. There is a shortage of existing research on the consequences of endodontic disease on systemic health. To date, few studies have investigated a potential correlation between AP and CVD, and their findings are inconclusive.
Apical Periodontitis (AP) represents an infection of endodontic origin that leads to an inflammatory state. Chronic inflammations, when at the systemic level, can trigger several diseases. Inflammatory mediators are known to lead to endothelial dysfunction (ED) and to play a key role in the initiation and progression of atherosclerosis, the main cause of coronary heart disease (CHD). Therefore, chronic dental inflammation, such as AP could provide an environment conducive to cardiovascular events (CVEs). There are suggestions that AP and cardiovascular diseases (CVDs) share similar pathogenesis and molecular actors. APs are common in the general population and could perpetuate systemic inflammation and, in turn, contribute to the increased incidence of CVD. There is a shortage of existing research on the consequences of endodontic disease on systemic health. To date, few studies have investigated a potential correlation between AP and CVD, and their findings are inconclusive.
Description
Keywords
Periodontite apical Doença cardiovascular Inflamação Infeção Endodontia Apical periodontitis Cardiovascular disease Inflammation Infection Endodontics