Acid/Base Properties of β-Blockers and Benzodiazepines in Sodium Dodecyl Sulfate Micelles. A Spectrophotometric and Potentiometric Study

de Castro, Baltazar; Gameiro, Paula; Guimarães, Carla; Lima, José L.F.C.; Reis, Salette

http://hdl.handle.net/10284/8257

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
J. Pharm. Sci. 1998.pdf		57.73 KB	Adobe PDF	Download

Send Feedback

Authors

Abstract(s)

The effect of sodium dodecyl sulfate (SDS) micelles on the acid-base properties of two family of pharmaceutical drugs (beta-blockers and benzodiazepines) at 25 degrees C and I = 0.1 M NaCl have been studied. The characterization of the several solution equilibria for the system drug/SDS micelle solution was performed by potentiometry and spectrophotometry, below and above the critical micelle concentration (cmc). Two widely used models have been applied to quantify the effect of micelles on the pKa of the drugs, and the results obtained point to different interactions of each family of drugs with the micelles.

Keywords

Adrenergic beta-Antagonists Benzodiazepines Electrochemistry Hydrogen-Ion Concentration Micelles Models, Chemical Sodium Dodecyl Sulfate Spectrophotometry, Ultraviolet