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Publication
Avaliação do pH salivar em pacientes submetidos a radioterapia à região de cabeça e pescoço
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_24381 | 1.45 MB | Adobe PDF |
Advisor(s)
Abstract(s)
A disfunção das glândulas salivares, como sequela da Radioterapia (RT) traduz-se geralmente em hipofunção salivar e consequente diminuição do pH. Este estudo avaliou o comportamento do pH salivar num grupo de 35 indivíduos submetidos a RT com fracionamento convencional, por tumores malignos da região de cabeça e pescoço. O acompanhamento foi obtido através de três avaliações a cada indivíduo. A primeira avaliação foi realizada antes do tratamento, a segunda após 15 sessões de tratamento e a última depois de terminado o tratamento. O pH salivar foi determinado através de indicadores de alaranjado de metilo e azul de bromotimol, colocados na face dorsal da língua. A média do valor de pH registada antes do tratamento foi 6,69. A medição intermédia demonstrou diminuição do valor de pH da saliva para 6.37, baixando para 6,31 até ao final do tratamento (p>0,05). Estes resultados demonstraram que a RT, no tratamento de tumores da cabeça e do pescoço, parece reduzir o pH salivar, sendo este valor dose-dependente.
The dysfunction of the salivary glands, as an effect of radiotherapy (RT), usually generates a salivary hypofunction and subsequent decrease of the pH value. This study aimed to evaluate the salivary pH behaviour in a group of 35 individuals under RT with conventional fractionation, for malignant tumours of the head and neck regions. The follow-up was obtained through three assessments to each individual. The first evaluation was conducted before treatment, the second one after 15 treatment sessions and the last one at the end of the treatment. The salivary pH was determined by methyl orange indicator and bromothymol blue indicator placed on the dorsal surface of the tongue. The average pH recorded before the treatment was 6.69. The intermediate measurement showed a diminution of the saliva pH value to 6:37, dropping to 6.31 by the end of treatment (p> 0.05). These results revealed that the RT for the treatment of tumours of the head and neck regions appears to reduce the salivary pH value, which is dose-dependent.
The dysfunction of the salivary glands, as an effect of radiotherapy (RT), usually generates a salivary hypofunction and subsequent decrease of the pH value. This study aimed to evaluate the salivary pH behaviour in a group of 35 individuals under RT with conventional fractionation, for malignant tumours of the head and neck regions. The follow-up was obtained through three assessments to each individual. The first evaluation was conducted before treatment, the second one after 15 treatment sessions and the last one at the end of the treatment. The salivary pH was determined by methyl orange indicator and bromothymol blue indicator placed on the dorsal surface of the tongue. The average pH recorded before the treatment was 6.69. The intermediate measurement showed a diminution of the saliva pH value to 6:37, dropping to 6.31 by the end of treatment (p> 0.05). These results revealed that the RT for the treatment of tumours of the head and neck regions appears to reduce the salivary pH value, which is dose-dependent.
Description
Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária
Keywords
Neoplasia de cabeça e pescoço Glândulas salivares Hipossalivação PH Saliva Radioterapia Head and neck cancer Salivary glands Hyposalivation PH Saliva Radiotherapy