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Visão do futuro da endodontia: células estaminais pluripotentes na regeneração tecidular – revisão narrativa
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 36770 | 605.04 KB | Adobe PDF |
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Abstract(s)
O tratamento do canal radicular em ápices maduros, a apexificação em ápices imaturos ou a extração têm sido as abordagens técnicas mais consensuais, nos casos de necrose pulpar. Equacionar uma abordagem regenerativa pode ser o tratamento ideal, remove-se a polpa necrótica e substitui-se por tecido pulpar regenerado revitalizando o dente.
A endodontia regenerativa inclui técnicas de revascularização pulpar, terapia com células estaminais, implantação pulpar e scaffolds, impressão tridimensional celular e terapia genética. Continuam a existir barreiras legais e éticas que atrasam a evolução de futuros protocolos pelo que a investigação neste sentido tem sido feita devagar.
Esta monografia pretende sumariar os métodos e requisitos necessários para a endodontia regenerativa com as diversas populações de células estaminais dentárias, bem como analisar perspetivas futuras.
Root canal treatment in mature apices, apexification in immature apices, or extraction have been the most consensual technical approaches in cases of pulp necrosis. Considering a regenerative approach may be the ideal treatment, removing the necrotic pulp and replacing it with regenerated pulp tissue revitalizing the tooth. Regenerative endodontics includes pulp revascularization techniques, stem cell therapy, pulp implantation and scaffolds, three-dimensional cell printing, and gene therapy. There are still legal and ethical barriers that delay the evolution of future protocols, so research in this direction has been done slowly. This monograph aims to summarize the methods and requirements necessary for regenerative endodontics with the various populations of dental stem cells, as well as to analyze future perspectives.
Root canal treatment in mature apices, apexification in immature apices, or extraction have been the most consensual technical approaches in cases of pulp necrosis. Considering a regenerative approach may be the ideal treatment, removing the necrotic pulp and replacing it with regenerated pulp tissue revitalizing the tooth. Regenerative endodontics includes pulp revascularization techniques, stem cell therapy, pulp implantation and scaffolds, three-dimensional cell printing, and gene therapy. There are still legal and ethical barriers that delay the evolution of future protocols, so research in this direction has been done slowly. This monograph aims to summarize the methods and requirements necessary for regenerative endodontics with the various populations of dental stem cells, as well as to analyze future perspectives.
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Keywords
Células estaminais dentárias Regeneração pulpar Scaffold Fatores de crescimento Células de pluripotência induzidas Polpa Dental stem cells Pulp regeneration Scaffold Growth factors Induced pluripotency cells Pulp