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The effects of ionizing radiation on gut microbiota, a systematic review

dc.contributor.authorFernandes, Ana
dc.contributor.authorOliveira, Ana
dc.contributor.authorSoares, Raquel
dc.contributor.authorBarata, Pedro
dc.date.accessioned2022-03-04T16:59:13Z
dc.date.available2022-03-04T16:59:13Z
dc.date.issued2021
dc.description.abstractBackground: The human gut microbiota is defined as the microorganisms that collectively inhabit the intestinal tract. Its composition is relatively stable; however, an imbalance can be precipitated by various factors and is known to be associated with various diseases. Humans are daily exposed to ionizing radiation from ambient and medical procedures, and gastrointestinal side effects are not rare. Methods: A systematic search of PubMed, EMBASE, and Cochrane Library databases was conducted. Primary outcomes were changes in composition, richness, and diversity of the gut microbiota after ionizing radiation exposure. Standard methodological procedures expected by Cochrane were used. Results: A total of 2929 nonduplicated records were identified, and based on the inclusion criteria, 11 studies were considered. Studies were heterogeneous, with differences in population and outcomes. Overall, we found evidence for an association between ionizing radiation exposure and dysbiosis: reduction in microbiota diversity and richness, increase in pathogenic bacteria abundance (Proteobacteria and Fusobacteria), and decrease in beneficial bacteria (Faecalibacterium and Bifidobacterium). Conclusions: This review highlights the importance of considering the influence of ionizing radiation exposure on gut microbiota, especially when considering the side effects of abdominal and pelvic radiotherapy. Better knowledge of these effects, with larger population studies, is needed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/nu13093025pt_PT
dc.identifier.eissn2072-6643
dc.identifier.urihttp://hdl.handle.net/10284/10813
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.subjectMicrobiomept_PT
dc.subjectMicrobiotapt_PT
dc.subjectIntestinal microbiomept_PT
dc.subjectGut microbiotapt_PT
dc.subjectMicroflorapt_PT
dc.subjectIonizing radiationpt_PT
dc.subjectRadiotherapypt_PT
dc.subjectRadiation effectspt_PT
dc.titleThe effects of ionizing radiation on gut microbiota, a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue9pt_PT
oaire.citation.startPage3025pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume13pt_PT
person.familyNameBarata
person.givenNamePedro
person.identifier1143078
person.identifier.ciencia-id1A18-987D-45C3
person.identifier.orcid0000-0002-4537-5450
person.identifier.scopus-author-id55043534700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8d0c119d-146f-4548-9e03-b16d0050ef08
relation.isAuthorOfPublication.latestForDiscovery8d0c119d-146f-4548-9e03-b16d0050ef08

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