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Cationic solid lipid nanoparticles (cSLN): structure, stability and DNA binding capacity correlation studies

2011-11Journal article Restricted access
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dc.contributor.authorDoktorovova, S.
dc.contributor.authorShegokar, R.
dc.contributor.authorRakovsky, E.
dc.contributor.authorGonzalez-Mira, E.
dc.contributor.authorLopes, Carla Martins
dc.contributor.authorSilva, A.M.
dc.contributor.authorMartins-Lopes, P.
dc.contributor.authorMuller, R.H.
dc.contributor.authorSouto, Eliana B.
dc.date.accessioned2020-10-14T08:40:54Z
dc.date.available2020-10-14T08:40:54Z
dc.date.issued2011-11
dc.date.updated2020-07-24T16:28:06Z
dc.description.abstractCationic solid lipid nanoparticles (cSLN) are promising lipid nanocarriers for intracellular gene delivery based on well-known and widely accepted materials. cSLN containing single-chained cationic lipid cetyltrimethylammonium bromide were produced by high pressure homogenization and characterized in terms of(a) particle size distribution by photon correlation spectroscopy (PCS) and laser diffractometry (LD), (b) thermal behaviour using differential scanning calorimetry (DSC) and (c) the presence of various polymorphic phases was confirmed by X-ray diffraction (WAXD). SLN composed of Imwitor 900PTM (IMW) showed different pDNA stability and binding capacity in comparison to those of Compritol 888 ATOTM (COM). IMW-SLN, having z-ave = 138–157 nm and d(0.5) = 0.15–0.158 m could maintain this size for 14 days at room temperature. COM-SLN had z-ave = 334 nm and d(0.5) = 0.42 m on the day of production and could maintain similar size during 90 days. IMW-SLN revealed improved pDNA binding capacity. We attempted to explain these differences by differentinteractions between the solid lipid and the tested cationic lipid.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ijpharm.2011.08.042pt_PT
dc.identifier.eid2-s2.0-80054694297
dc.identifier.issn0378-5173
dc.identifier.slugcv-prod-336974
dc.identifier.urihttp://hdl.handle.net/10284/9054
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.subjectSolid lipid nanoparticlespt_PT
dc.subjectGene deliverypt_PT
dc.subjectDifferential scanning calorimetrypt_PT
dc.subjectWide angle X-ray scatteringpt_PT
dc.subjectStability studiespt_PT
dc.titleCationic solid lipid nanoparticles (cSLN): structure, stability and DNA binding capacity correlation studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage349pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage341pt_PT
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume420pt_PT
person.familyNameLopes
person.familyNameSouto
person.givenNameCarla
person.givenNameEliana B.
person.identifier.ciencia-id901D-160C-633E
person.identifier.ciencia-id8D1B-21CC-90F7
person.identifier.orcid0000-0001-5080-032X
person.identifier.orcid0000-0002-9737-6017
person.identifier.ridM-4689-2016
person.identifier.ridL-9813-2014
person.identifier.scopus-author-id26649517700
person.identifier.scopus-author-id8839435500
rcaap.cv.cienciaid901D-160C-633E | Carla Martins Lopes
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublicationb9f031fa-7f68-4196-b9c6-9f17cd542f12
relation.isAuthorOfPublication.latestForDiscoveryd2a48cfe-9258-4916-99be-bbcb710f6605

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