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1,2-dihydroxyxanthone: effect on A375-C5 melanoma cell growth associated with interference with THP-1 human macrophage activity

2019Journal article Restricted access
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dc.contributor.authorSilva, Viviana
dc.contributor.authorCerqueira, Fátima
dc.contributor.authorNazareth, Nair
dc.contributor.authorMedeiros, R.
dc.contributor.authorSarmento, Amélia
dc.contributor.authorSousa, Emília
dc.contributor.authorPinto, Madalena
dc.date.accessioned2021-07-13T09:46:25Z
dc.date.available2021-07-13T09:46:25Z
dc.date.issued2019
dc.description.abstractXanthones have been suggested as prospective candidates for cancer treatment. 1,2- dihydroxyxanthone (1,2-DHX) is known to interfere with the growth of several cancer cell lines. We investigated the effects of 1,2-DHX on the growth of the A375-C5 melanoma cell line and THP-1 human macrophage activity. 1,2-DHX showed a moderate growth inhibition of A375-C5 melanoma cells (concentration that causes a 50% inhibition of cell growth (GI50) = 55.0 ±2.3 µM), but strongly interfered with THP-1 human macrophage activity. Supernatants from lipopolysaccharide (LPS)-stimulated THP-1 macrophage cultures exposed to 1,2-DHX significantly increased growth inhibition of A375-C5 cells, when compared to supernatants from untreated LPS-stimulated macrophages or to direct treatment with 1,2-DHX only. 1,2-DHX decreased THP-1 secretion of interleukin-1β (IL-1β) and interleukin-10 (IL-10), but stimulated tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) production. This xanthone also inhibited nitric oxide (NO) production by RAW 264.7 murine macrophages, possibly through inhibition of inducible NO synthase production. In conclusion, these findings suggest a potential impact of 1,2-DHX in melanoma treatment, not only due to a direct effect on cancer cells but also by modulation of macrophage activity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ph12020085pt_PT
dc.identifier.issn1424-8247
dc.identifier.urihttp://hdl.handle.net/10284/10071
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.subjectXanthonespt_PT
dc.subjectMelanomapt_PT
dc.subjectMacrophagespt_PT
dc.subjectCytokinespt_PT
dc.title1,2-dihydroxyxanthone: effect on A375-C5 melanoma cell growth associated with interference with THP-1 human macrophage activitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.startPage85pt_PT
oaire.citation.titlePharmaceuticalspt_PT
oaire.citation.volume12pt_PT
person.familyNameCerqueira
person.familyNameMedeiros
person.givenNameFátima
person.givenNameRui
person.identifier812695
person.identifier37604
person.identifier.ciencia-idCF14-52ED-5DA0
person.identifier.ciencia-idC51F-5DBE-9C51
person.identifier.orcid0000-0003-4513-4654
person.identifier.orcid0000-0003-3010-8373
person.identifier.ridM-7557-2013
person.identifier.ridC-7938-2009
person.identifier.scopus-author-id6603346911
person.identifier.scopus-author-id7006241641
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2705e35c-97f6-4de2-bbf1-d680342760e9
relation.isAuthorOfPublication5ffb7965-d9af-4ba1-a81b-b0aed28de206
relation.isAuthorOfPublication.latestForDiscovery2705e35c-97f6-4de2-bbf1-d680342760e9

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