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Protective activity of Hypericum androsaemum infusion against tert-butyl hydroperoxide-induced oxidative damage in isolated rat hepatocytes

2004Journal article Restricted access
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dc.contributor.authorValentão, Patrı́cia
dc.contributor.authorCarvalho, Márcia
dc.contributor.authorFernandes, Eduarda
dc.contributor.authorCarvalho, Félix
dc.contributor.authorAndrade, Paula Branquinho
dc.contributor.authorSeabra, Rosa Maria
dc.contributor.authorBastos, Maria de Lourdes
dc.date.accessioned2021-07-02T08:54:46Z
dc.date.available2021-07-02T08:54:46Z
dc.date.issued2004
dc.description.abstractHypericum androsaemum L. (Guttiferae) is a medicinal plant with antioxidant activity. Increasing evidence regarding free radical generating agents suggests that hepatotoxic-related disorders may involve reactive oxygen species (ROS). The purpose of this study was to investigate the protective effect of Hypericum androsaemum infusion on isolated rat hepatocytes oxidative injury induced by tert-butyl hydroperoxide (t-BHP). The results showed that pretreatment of the cells with this infusion (16, 62 and 250 microg/ml) prevented the leakage of lactate dehydrogenase (LDH) and lipid peroxidation caused by a 30-min treatment with t-BHP (1mM). However, infusion-induced alterations on glutathione homeostasis were noticed, as it was observed by the increase in glutathione oxidised form (GSSG) and depletion in total glutathione levels, which indicates that plant-derived antioxidant extracts may not be considered a generalised way of treating pro-oxidant-related diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.jep.2004.02.004pt_PT
dc.identifier.issn0378-8741
dc.identifier.urihttp://hdl.handle.net/10284/10009
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationThe authors are grateful to the Agência Inovação and PRAXIS XXI (PLANTAMEDI project) for financial support of this work. P. Valentão is indebted to Fundação para a Ciência e a Tecnologia for a Ph.D. grant (PRAXIS XXI/BD/15740/98).pt_PT
dc.subjectHypericum androsaemumpt_PT
dc.subjectIsolated hepatocytespt_PT
dc.subjectTert-Butyl hydroperoxidept_PT
dc.subjectHepatoprotective activitypt_PT
dc.titleProtective activity of Hypericum androsaemum infusion against tert-butyl hydroperoxide-induced oxidative damage in isolated rat hepatocytespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage84pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage79pt_PT
oaire.citation.titleJournal of Ethnopharmacologypt_PT
oaire.citation.volume92pt_PT
person.familyNameCarvalho
person.givenNameMarcia
person.identifier2017111
person.identifier.ciencia-id8B10-171E-E63E
person.identifier.orcid0000-0001-9884-4751
person.identifier.ridD-5999-2013
person.identifier.scopus-author-id7201413997
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3837b828-ba57-47f7-a811-cce65e4922c6
relation.isAuthorOfPublication.latestForDiscovery3837b828-ba57-47f7-a811-cce65e4922c6

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