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Omega 3 and resveratrol loaded lipid nanosystems for potential use as topical formulations in autoimmune, inflammatory, and cancerous skin diseases

2021-08-04Journal article Open access
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dc.contributor.authorCaldas, Ana Rita
dc.contributor.authorCatita, José
dc.contributor.authorMachado, Raúl
dc.contributor.authorRibeiro, Artur
dc.contributor.authorCerqueira, Fátima
dc.contributor.authorHorta, Bruno
dc.contributor.authorMedeiros, R.
dc.contributor.authorLúcio, Marlene
dc.contributor.authorLopes, Carla Martins
dc.date.accessioned2021-09-15T11:21:04Z
dc.date.available2021-09-15T11:21:04Z
dc.date.issued2021-08-04
dc.description.abstractResveratrol (RSV) and omega 3 (ω3), because of their biological favorable properties, have become subjects of interest for researchers in dermocosmetic and pharmaceutical industries; however, these bioactives present technological limitations that hinder their effective delivery to the target skin layer. To overcome the stability and skin permeation limitations of free bioactives, this work proposes a combined strategy involving two different lipid nanosystems (liposomes and lipid nanoparticles) that include ω3 in their lipid matrix. Additionaly, RSV is only encapsulated in liposomes that provid an adequate amphiphilic environment. Each formulation is thoroughly characterized regarding their physical–chemical properties. Subsequently, the therapeutic performance of the lipid nanosystems is evaluated based on their protective roles against lipid peroxidation, as well as inhibition of cicloxygenase (COX) and nitric oxid (NO) production in the RWA264.7 cell line. Finally, the lipid nanosystems are incorporated in hydrogel to allow their topical administration, then rheology, occlusion, and RSV release–diffusion assays are performed. Lipid nanoparticles provide occlusive effects at the skin surface. Liposomes provide sustained RSV release and their flexibility conferred by edge activator components enhances RSV diffusion, which is required to reach NO production cells and COX cell membrane enzymes. Overall, the inclusion of both lipid nanosystems in the same semisolid base constitutes a promising strategy for autoimmune, inflammatory, and cancerous skin diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCaldas, A.R.; Catita, J.; Machado, R.; Ribeiro, A.; Cerqueira, F.; Horta, B.; Medeiros, R.; Lúcio, M.; Lopes, C.M. Omega-3- and Resveratrol-Loaded Lipid Nanosystems for Potential Use as Topical Formulations in Autoimmune, Inflammatory, and Cancerous Skin Diseases. Pharmaceutics 2021, 13, 1202. https://doi.org/10.3390/ pharmaceutics13081202pt_PT
dc.identifier.doi10.3390/pharmaceutics13081202pt_PT
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/10284/10214
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationFCT/MCTES—Foundation for Science and Technology I.P. from the Minister of Science, Technology, and Higher Education (PIDDAC) and European Regional Development Fund (ERDF) by the COMPETE—Programa Operacional Factores de Competitividade (POFC) through the project CONCERT (POCI-01-0145-FEDER-032651 and PTDC/NAN-MAT/326512017) and the Strategic Funding UID/Multi/04546/2019, UIDP/04423/2020 (Group of Natural Products and Medicinal Chemistry CIIMAR), and “Contrato-Programa” UIDB/04469/2020 (CF-UM-UP) and UIDB/04050/2020 (CBMA), and UIDB/ 04469/2020 (CEB), as well as the Research Center of the Portuguese Oncology Institute of Porto (project no. PI86-CI-IPOP-66-2019), and BioTecNorte operation (NORTE-01-0145-FEDER- 000004) funded by the European Regional Development Fund under the scope of Norte 2020 - Programa Operacional Regional do Norte.pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1999-4923/13/8/1202/htmpt_PT
dc.subjectResveratrolpt_PT
dc.subjectOmega 3pt_PT
dc.subjectTopical skin administrationpt_PT
dc.subjectLipid nanosystemspt_PT
dc.subjectCOX inhibitorspt_PT
dc.subjectNO inhibitory effectpt_PT
dc.subjectAntioxidantpt_PT
dc.titleOmega 3 and resveratrol loaded lipid nanosystems for potential use as topical formulations in autoimmune, inflammatory, and cancerous skin diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue8pt_PT
oaire.citation.titlePharmaceuticspt_PT
oaire.citation.volume13pt_PT
person.familyNameMorais Catita
person.familyNameCerqueira
person.familyNameMedeiros
person.familyNameLopes
person.givenNameJose Antonio
person.givenNameFátima
person.givenNameRui
person.givenNameCarla
person.identifierJose Catita
person.identifier812695
person.identifier37604
person.identifier.ciencia-idB41E-3287-E706
person.identifier.ciencia-idCF14-52ED-5DA0
person.identifier.ciencia-idC51F-5DBE-9C51
person.identifier.ciencia-id901D-160C-633E
person.identifier.orcid0000-0001-7270-5702
person.identifier.orcid0000-0003-4513-4654
person.identifier.orcid0000-0003-3010-8373
person.identifier.orcid0000-0001-5080-032X
person.identifier.ridM-7557-2013
person.identifier.ridC-7938-2009
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id6507275921
person.identifier.scopus-author-id6603346911
person.identifier.scopus-author-id7006241641
person.identifier.scopus-author-id26649517700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication24bb2971-32ae-429b-b397-145dacb66a5a
relation.isAuthorOfPublication2705e35c-97f6-4de2-bbf1-d680342760e9
relation.isAuthorOfPublication5ffb7965-d9af-4ba1-a81b-b0aed28de206
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublication.latestForDiscovery2705e35c-97f6-4de2-bbf1-d680342760e9

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