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Biosimilar medicines used for cancer therapy in Europe: a review

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dc.contributor.authorSantos, Sofia B.
dc.contributor.authorLobo, José M. Sousa
dc.contributor.authorSilva, Ana Catarina
dc.date.accessioned2021-04-28T08:14:38Z
dc.date.available2021-04-28T08:14:38Z
dc.date.issued2019
dc.description.abstractThis article provides an updated review of the biosimilar medicines approved for cancer therapy in the European Union (EU). First we discuss the most relevant aspects for the development and approval of biosimilar medicines. We then present the oncological biosimilar drugs currently used, which include epoetins (alpha and zeta), filgrastim, and monoclonal antibodies (rituximab, trastuzumab and bevacizumab). Among the clinical applications of biosimilar medicines, cancer therapy remains the main target area and more approved biosimilars are expected over the next few years, providing cost-effective drugs to more patients. Furthermore, comprehensive pharmacovigilance studies are going on, monitoring the marketed biosimilars, and providing more feasible information to clinicians regarding the safety and efficacy of these medications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.drudis.2018.09.011pt_PT
dc.identifier.issn1359-6446
dc.identifier.urihttp://hdl.handle.net/10284/9807
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAnimalspt_PT
dc.subjectAntineoplastic Agentspt_PT
dc.subjectBiosimilar Pharmaceuticalspt_PT
dc.subjectEuropept_PT
dc.subjectHumanspt_PT
dc.subjectNeoplasmspt_PT
dc.titleBiosimilar medicines used for cancer therapy in Europe: a reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage299pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage293pt_PT
oaire.citation.titleDrug Discovery Todaypt_PT
oaire.citation.volume24pt_PT
person.familyNameSilva
person.givenNameAna Catarina
person.identifier953153
person.identifier.ciencia-id5C1D-ED22-0D64
person.identifier.orcid0000-0001-6923-0232
person.identifier.ridF-1875-2017
person.identifier.scopus-author-id57028697500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67e7f707-32ec-444a-a20d-a17f8e6e7c21
relation.isAuthorOfPublication.latestForDiscovery67e7f707-32ec-444a-a20d-a17f8e6e7c21

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