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Avobenzone-loaded and omega-3-enriched lipid formulations for production of UV blocking sunscreen gels and textiles

2021Journal article Restricted access
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dc.contributor.authorCaldas, Ana Rita
dc.contributor.authorFaria, Maria João
dc.contributor.authorRibeiro, Artur
dc.contributor.authorMachado, Raúl
dc.contributor.authorGonçalves, Hugo
dc.contributor.authorGomes, Andreia C.
dc.contributor.authorSoares, Graça
dc.contributor.authorLopes, Carla Martins
dc.contributor.authorLúcio, Marlene
dc.date.accessioned2021-09-13T12:24:34Z
dc.date.available2021-09-13T12:24:34Z
dc.date.issued2021
dc.description.abstractGiven the growing harmful effects of ultraviolet (UV) radiation there is an urgent need to develop effective strategies to prevent skin damages. Therefore, hydrogel or cotton and wool fabrics were impregnated with avobenzone (AVO)-loaded and omega-3 (ω3)-enriched lipid formulations (liposomes – LIP, nanostructured lipid carriers – NLC and solid lipid nanoparticles – SLN) to obtain UV blocking sunscreen gel or functional textiles. To evaluate the physicochemical characteristics of AVO and the sun blocking performance of the formulations incorporated in hydrogels or textiles, in silico and in vitro studies were conducted. In silico studies indicated that AVO can permeate the epithelium, and lipid formulations could be a promising strategy for incorporating and retaining AVO. Furthermore, all lipid formulations showed an entrapment efficiency of AVO of ca. 100 % and a loading capacity between 7 and 12 %. The presence of AVO was confirmed by ATR-FTIR and SEM analysis. In vitro release profiles showed that the UV filter was almost totally retained within the lipid formulations (release of only 4.2 ± 2.5 % at 6 h) with similar results obtained for textiles. After assessing the cytotoxicity, cationic formulations loaded with AVO showed to be cytotoxic in a human keratinocyte cell line (NCTC 2544 cells) as opposed to AVO-loaded anionic formulations after 24 h. Photodegradation studies demonstrated that lipid formulations have photoprotective properties by stabilizing AVO but the photoprotective role could not be attributed to ω3 despite its antioxidant effect evaluated by ATR-FTIR. Overall, it is possible to conclude that SLN and NLC were more effective as UV protectors than LIP, and that each formulation can have different applications. Negatively charged NLC and SLN can be used for UV protection in contact with the skin either in sunscreen gel or clothing, while positively charged NLC and SLN should be reserved as UV protectors of tissues not in contact with skin (e.g., umbrellas, curtains, etc.).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAna R. Caldas, Maria J. Faria, Artur Ribeiro, Raul Machado, Hugo Gonçalves, Andreia C. Gomes, Graça M.B. Soares, Carla M. Lopes, Marlene Lúcio, Avobenzone-loaded and omega-3-enriched lipid formulations for production of UV blocking sunscreen gels and textiles, Journal of Molecular Liquids, 2021, 116965.pt_PT
dc.identifier.doi10.1016/j.molliq.2021.116965pt_PT
dc.identifier.issn0167-7322
dc.identifier.urihttp://hdl.handle.net/10284/10208
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationFundação para a Ciência e Tecnologia (FCT I.P.) in the framework of the Strategic Funding [UID/ FIS/04650/2019 and UIDB/04469/2020], ‘‘Contrato-Programa” UIDB/ and by the project CONCERT [POCI-01-0145-FEDER-032651 and PTDC/NAN-MAT/326512017], co-financed by the European Regional Development Fund (ERDF), through COMPETE 2020, under Portugal 2020, and FCT I.Ppt_PT
dc.relation.publisherversionhttps://doi.org/10.1016/j.molliq.2021.116965pt_PT
dc.subjectChemical UV filterspt_PT
dc.subjectPhysical UV filterspt_PT
dc.subjectLipid nanocarrierspt_PT
dc.subjectUV blocking sunscreen gelpt_PT
dc.subjectFunctional textilespt_PT
dc.titleAvobenzone-loaded and omega-3-enriched lipid formulations for production of UV blocking sunscreen gels and textilespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Molecular Liquidspt_PT
person.familyNameLopes
person.givenNameCarla
person.identifier.ciencia-id901D-160C-633E
person.identifier.orcid0000-0001-5080-032X
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id26649517700
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublication.latestForDiscoveryd2a48cfe-9258-4916-99be-bbcb710f6605

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