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Year-long rhinovirus infection is influenced by atmospheric conditions, outdoor air virus presence, and immune system-related genetic polymorphisms

2019Journal article Restricted access
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dc.contributor.authorRodrigues, Ana Filipa
dc.contributor.authorSantos, Ana Mafalda
dc.contributor.authorFerreira, Ana Maria
dc.contributor.authorMarino, Roberta
dc.contributor.authorBarreira, Maria Esmeralda
dc.contributor.authorCabeda, José Manuel
dc.date.accessioned2021-01-26T00:33:43Z
dc.date.available2021-01-26T00:33:43Z
dc.date.issued2019
dc.description.abstractRhinovirus is a common picornavirus with over 150 serotypes and three species, which is responsible for half of the human common cold cases. In people with chronic respiratory conditions and elders, it may also cause life-threatening diseases. Transmission routes are not definitively established but may involve direct human-to-human and indirect transmission (surfaces and aerosols based). In the present study, year-long presence of virus was tested by qPCR in the nostrils of young healthy volunteers and indoor and outdoor air samples. Results were correlated to atmospheric conditions (meteorological and air quality parameters) and voluntaries immune system-related genetic polymorphisms (TOLLIP rs5743899, IL6 rs1800795, IL1B rs16944, TNFA rs1800629) typed by PCR-RFLP. Nasal samples showed increased frequency and viral titers of Rhinovirus in spring and autumn. No indoor air samples tested positive for Rhinovirus, whereas outdoor air samples tested positive in late autumn. Sun radiation, atmospheric SO2, and benzene levels correlated with nostrils Rhinovirus detection. Both IL6 and TOLLIP polymorphisms but not TNFA or IL1B influenced Rhinovirus detection in the nostrils of voluntaries. Taken together, the results indicate that Rhinovirus circulation is determined by environmental conditions (weather, air-borne virus, and air pollution) and genetically encoded individual variation in immunity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s12560-019-09397-xpt_PT
dc.identifier.issn1867-0334
dc.identifier.issn1867-0342
dc.identifier.urihttp://hdl.handle.net/10284/9240
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationUID/ Multi/04546/2016pt_PT
dc.relationUFP Energy, Environment and Health Research Unit
dc.subjectRhinoviruspt_PT
dc.subjectEnvironmentpt_PT
dc.subjectPolymorphismpt_PT
dc.subjectAir-borne viruspt_PT
dc.subjectViral susceptibilitypt_PT
dc.titleYear-long rhinovirus infection is influenced by atmospheric conditions, outdoor air virus presence, and immune system-related genetic polymorphismspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleUFP Energy, Environment and Health Research Unit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04546%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04546%2F2019/PT
oaire.citation.endPage349pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage340pt_PT
oaire.citation.titleFood and Environmental Virologypt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream5876
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarreira
person.familyNameManuel Baptista Cabeda
person.givenNameMaria Esmeralda Reis
person.givenNameJosé
person.identifier.ciencia-id341E-D243-5BE3
person.identifier.ciencia-id3F17-D327-35C3
person.identifier.orcid0000-0001-5880-1669
person.identifier.orcid0000-0002-5117-2326
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoveryc928b66f-c6b6-40b1-80ff-9831007c88eb
relation.isProjectOfPublication14f38512-c5ef-4626-9713-bc4b1707fd06
relation.isProjectOfPublicationa68076ed-402e-478b-b615-c11043b9228d
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