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Physical and chemical stimuli-responsive drug delivery systems: targeted delivery and main routes of administration

2013Journal article Restricted access
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dc.contributor.authorLopes, Joana R.
dc.contributor.authorSantos, Gory
dc.contributor.authorBarata, Pedro
dc.contributor.authorOliveira, Rita
dc.contributor.authorLopes, Carla Martins
dc.date.accessioned2020-10-15T08:17:44Z
dc.date.available2020-10-15T08:17:44Z
dc.date.issued2013
dc.date.updated2020-07-24T16:07:57Z
dc.description.abstractIn the area of drug delivery, novel tools and technological approaches have captured the attention of researchers in order to improve the performance of conventional therapeutics and patient compliance to pharmacological therapy. Stimuli-responsive drug delivery systems (DDS) appear as a promising approach to control and target drug delivery. When these DDS are administered, the drug release is activated and then modulated through some action or external input and facilitated by the energy supplied externally. The stimuli responsible to activate the drug release can be classified into three types according to their nature or the type of energy applied: physical (e.g. magnetic field, electric field, ultrasound, temperature and osmotic pressure); chemical (e.g. pH, ionic strength and glucose); and biological (enzymes and endogenous receptors). The present review gives an overview of the most significant physical and chemical stimuliresponsive DDS and elucidates about their current and relevant applications in controlled and targeted drug delivery attending different routes of administration.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2174/13816128113199990698pt_PT
dc.identifier.eid2-s2.0-84890913951
dc.identifier.issn1873-4286
dc.identifier.slugcv-prod-336989
dc.identifier.urihttp://hdl.handle.net/10284/9060
dc.language.isoengpt_PT
dc.publisherBentham Science Publisherspt_PT
dc.subjectStimuli-responsive DDSpt_PT
dc.subjectChemical stimulipt_PT
dc.subjectPhysical stimulipt_PT
dc.subjectBiological stimulipt_PT
dc.subjectControlled drug releasept_PT
dc.subjectSmart polymerspt_PT
dc.subjectTargeted DDSpt_PT
dc.subjectSpecific deliverypt_PT
dc.titlePhysical and chemical stimuli-responsive drug delivery systems: targeted delivery and main routes of administrationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage7194pt_PT
oaire.citation.issue41pt_PT
oaire.citation.startPage7169pt_PT
oaire.citation.titleCurrent Pharmaceutical Designpt_PT
oaire.citation.volume19pt_PT
person.familyNameBarata
person.familyNameLopes
person.givenNamePedro
person.givenNameCarla
person.identifier1143078
person.identifier.ciencia-id1A18-987D-45C3
person.identifier.ciencia-id901D-160C-633E
person.identifier.orcid0000-0002-4537-5450
person.identifier.orcid0000-0001-5080-032X
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id55043534700
person.identifier.scopus-author-id26649517700
rcaap.cv.cienciaid901D-160C-633E | Carla Martins Lopes
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8d0c119d-146f-4548-9e03-b16d0050ef08
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublication.latestForDiscoveryd2a48cfe-9258-4916-99be-bbcb710f6605

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