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Novel cerium doped glass-reinforced hydroxyapatite with antibacterial and osteoconductive properties for bone tissue regeneration

2015Artigo científico Acesso restrito
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dc.contributor.authorMorais, D S
dc.contributor.authorFernandes, S
dc.contributor.authorGomes, P S
dc.contributor.authorFernandes, M H
dc.contributor.authorSampaio, P
dc.contributor.authorFerraz, Maria Pia
dc.contributor.authorSantos, J D
dc.contributor.authorLopes, M A
dc.contributor.authorSooraj Hussain, N
dc.date.accessioned2019-09-12T15:18:15Z
dc.date.available2019-09-12T15:18:15Z
dc.date.issued2015
dc.description.abstractThe aim of this work was to develop a bioactive bone substitute with an effective antibacterial ability based on a cerium (Ce) doped glass-reinforced hydroxyapatite (GR-HA) composite. Developed composites were physicochemically characterized, using x-ray diffraction (XRD) analysis, SEM, energy dispersive x-ray spectroscopy (EDS), and flexural bending strength (FBS) tests. X-ray photoelectron spectroscopy (XPS) analysis was performed to analyze the oxidation state of Ce in the prepared doped glass. The antimicrobial activity of the composites was evaluated against Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa; whether the cytocompatibility profile was assayed with human osteoblastic-like cells (Mg-63 cell line). The results revealed that the Ce inclusion in the GR-HA matrix induced the antimicrobial ability of the composite. In addition, Ce-doped materials reported an adequate biological behavior following seeding of osteoblastic populations, by inducing cell adhesion and proliferation. Developed materials were also found to enhance the expression of osteoblastic-related genes. Overall, the developed GR-HA_Ce composite is a prospective candidate to be used within the clinical scenario with a successful performance due to the effective antibacterial properties and capability of enhancing the osteoblastic cell response.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1088/1748-6041/10/5/055008pt_PT
dc.identifier.urihttp://hdl.handle.net/10284/7840
dc.language.isoengpt_PT
dc.subjectAnti-Bacterial Agentspt_PT
dc.subjectBacterial Physiological Phenomenapt_PT
dc.subjectBone Regenerationpt_PT
dc.subjectBone Substitutespt_PT
dc.subjectCell Linept_PT
dc.subjectCell Survivalpt_PT
dc.subjectCeriumpt_PT
dc.subjectDrug Implantspt_PT
dc.subjectDurapatitept_PT
dc.subjectGlasspt_PT
dc.subjectHumanspt_PT
dc.subjectMaterials Testingpt_PT
dc.subjectOsteoblastspt_PT
dc.subjectTensile Strengthpt_PT
dc.titleNovel cerium doped glass-reinforced hydroxyapatite with antibacterial and osteoconductive properties for bone tissue regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue5pt_PT
oaire.citation.startPage055008pt_PT
oaire.citation.volume10pt_PT
person.familyNameFerraz
person.givenNameMaria Pia
person.identifier.ciencia-id7F16-B2FB-9AD4
person.identifier.orcid0000-0002-0274-106X
person.identifier.ridM-6316-2013
person.identifier.scopus-author-id7102012951
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7ba2ac59-40af-4ba1-b13e-4447f1686208
relation.isAuthorOfPublication.latestForDiscovery7ba2ac59-40af-4ba1-b13e-4447f1686208

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FCS - Artigos em Revistas Científicas Internacionais com Arbitragem Científica