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Lyotropic liquid crystalline 2D and 3D mesophases: advanced materials for multifunctional anticancer nanosystems

2023Journal article Restricted access
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dc.contributor.authorAraújo-Silva, Henrique
dc.contributor.authorTeixeira, Patricia V.
dc.contributor.authorGomes, Andreia C.
dc.contributor.authorLúcio, Marlene
dc.contributor.authorLopes, Carla Martins
dc.date.accessioned2024-01-29T16:16:31Z
dc.date.available2024-01-29T16:16:31Z
dc.date.issued2023
dc.description.abstractCancer remains a leading cause of mortality. Despite significant breakthroughs in conventional therapies, treatment is still far from ideal due to high toxicity in normal tissues and therapeutic inefficiency caused by short drug lifetime in the body and resistance mechanisms. Current research moves towards the development of multifunctional nanosystems for delivery of chemotherapeutic drugs, bioactives and/or radionuclides that can be combined with other therapeutic modalities, like gene therapy, or imaging to use in therapeutic screening and diagnosis. The preparation and characterization of Lyotropic Liquid Crystalline (LLC) mesophases self-assembled as 2D and 3D structures are addressed, with an emphasis on the unique properties of these nanoassemblies. A comprehensive review of LLC nanoassemblies is also presented, highlighting the most recent advances and their outstanding advantages as drug delivery systems, including tailoring strategies that can be used to overcome cancer challenges. Therapeutic agents loaded in LLC nanoassemblies offer qualitative and quantitative enhancements that are superior to conventional chemotherapy, particularly in terms of preferential accumulation at tumor sites and promoting enhanced cancer cell uptake, lowering tumor volume and weight, improving survival rates, and increasing the cytotoxicity of their loaded therapeutic agents. In terms of quantitative anticancer efficacy, loaded LLC nanoassemblies reduced the IC50 values from 1.4-fold against lung cancer cells to 125-fold against ovarian cancer cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAraújo-Silva, H., Teixeira, P. V., Gomes, A. C., Lúcio, M., & Lopes, C. M. (2023). Lyotropic liquid crystalline 2D and 3D mesophases: advanced materials for multifunctional anticancer nanosystems. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 189011. https://doi.org/10.1016/j.bbcan.2023.189011pt_PT
dc.identifier.doi10.1016/j.bbcan.2023.189011pt_PT
dc.identifier.eissn1879-2561
dc.identifier.issn0304-419X
dc.identifier.urihttp://hdl.handle.net/10284/12620
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.subjectCancerpt_PT
dc.subjectConventional therapiespt_PT
dc.subjectLyotropic liquid crystalline (LLC) mesophasespt_PT
dc.subjectCubosomespt_PT
dc.subjectHexosomespt_PT
dc.subjectSpongosomespt_PT
dc.titleLyotropic liquid crystalline 2D and 3D mesophases: advanced materials for multifunctional anticancer nanosystemspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.startPage189011pt_PT
oaire.citation.titleBiochimica et Biophysica Acta (BBA) - Reviews on Cancerpt_PT
oaire.citation.volume1878pt_PT
person.familyNameLopes
person.givenNameCarla
person.identifier.ciencia-id901D-160C-633E
person.identifier.orcid0000-0001-5080-032X
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id26649517700
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublication.latestForDiscoveryd2a48cfe-9258-4916-99be-bbcb710f6605

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