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Phytochemical profiles and inhibitory effect on free radical-induced human erythrocyte damage of Dracaena draco leaf: a potential novel antioxidant agent

2011Journal article Restricted access
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dc.contributor.authorSantos, Rui P.
dc.contributor.authorMendes, Lídia S.
dc.contributor.authorSilva, Branca M.
dc.contributor.authorGuedes de Pinho, Paula
dc.contributor.authorValentão, Patrícia
dc.contributor.authorAndrade, Paula B.
dc.contributor.authorPereira, José A.
dc.contributor.authorCarvalho, Márcia
dc.date.accessioned2021-07-02T16:31:05Z
dc.date.available2021-07-02T16:31:05Z
dc.date.issued2011
dc.description.abstractThe present study reports for the first time the metabolite profile and antioxidant activity of aqueous extract obtained from Dracaena draco L. leaf. Volatiles profile was determined by HS-SPME/GC-IT-MS, with 34 compounds being identified, distributed by distinct chemical classes: 2 alcohols, 5 aldehydes, 16 carotenoid derivatives and 8 terpenic compounds. Carotenoid derivative compounds constituted the most abundant class in leaf (representing 45% of total identified compounds). Phenolics profile was determined by HPLC/DAD and 9 constituents were identified: 2 hydroxycinnamic acid derivatives – 5-O-caffeoylquinic and 3,5-O-dicaffeoylquinic acids; 4 hydroxycinnamic acids – caffeic, p-coumaric, ferulic and sinapic acids and 3 flavonol glycosides – quercetin-3-O-rutinoside, kaempferol-3-O-glucoside and kaempferol-3-O-rutinoside. The most abundant phenolic compound is quercetin-3-O-rutinoside (representing 50.2% of total polyphenols). Organic acids composition was also characterised, by HPLC–UV and oxalic, citric, malic and fumaric acids were determined. Oxalic and citric acids were present in higher amounts (representing 47%, each). The antioxidant potential of this material was assessed by the ability to protect against free radical-induced biomembrane damage, using human erythrocyte as in vitro model. Leaf extract strongly protected the erythrocyte membrane from haemolysis (IC50 of 39 ± 11 μg/ml), in a time- and concentration-dependent manner. This is the first report showing that D. draco leaf is a promising antioxidant agent.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.foodchem.2010.07.021pt_PT
dc.identifier.issn0308-8146
dc.identifier.urihttp://hdl.handle.net/10284/10043
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectDracaena draco leafpt_PT
dc.subjectVolatilespt_PT
dc.subjectPolyphenolspt_PT
dc.subjectOrganic acidspt_PT
dc.subjectHaemolysis inhibitionpt_PT
dc.subjectAntioxidant activitypt_PT
dc.titlePhytochemical profiles and inhibitory effect on free radical-induced human erythrocyte damage of Dracaena draco leaf: a potential novel antioxidant agentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage934pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage927pt_PT
oaire.citation.titleFood Chemistrypt_PT
oaire.citation.volume124pt_PT
person.familyNameSilva
person.familyNameCarvalho
person.givenNameBranca Maria
person.givenNameMarcia
person.identifier1033309
person.identifier2017111
person.identifier.ciencia-idBD1F-B24D-89A9
person.identifier.ciencia-id8B10-171E-E63E
person.identifier.orcid0000-0002-5610-8024
person.identifier.orcid0000-0001-9884-4751
person.identifier.ridD-5999-2013
person.identifier.scopus-author-id7005615589
person.identifier.scopus-author-id7201413997
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication26c68872-1849-4895-a48d-72ccffbc02df
relation.isAuthorOfPublication3837b828-ba57-47f7-a811-cce65e4922c6
relation.isAuthorOfPublication.latestForDiscovery26c68872-1849-4895-a48d-72ccffbc02df

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