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In vitroantimicrobial activity and biocompatibility of propolis containing nanohydroxyapatite

2015Journal article Restricted access
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dc.contributor.authorGrenho, Liliana
dc.contributor.authorBarros, J
dc.contributor.authorFerreira, C
dc.contributor.authorSantos, V R
dc.contributor.authorMonteiro, F J
dc.contributor.authorFerraz, Maria Pia
dc.contributor.authorCortes, M E
dc.date.accessioned2019-09-23T07:49:36Z
dc.date.available2019-09-23T07:49:36Z
dc.date.issued2015
dc.description.abstractThe high number of biomaterial associated infections demands new strategies to prevent this problem. In this study the suitability of nanohydroxyapatite (nanoHA)-based surfaces containing two Brazilian extracts of propolis (green and red ones) to prevent bacterial growth and biofilm formation, as well as its non-cytotoxic nature, was investigated. Optical density, colony forming units and MTT reduction assay were used to assess the materials' antibacterial activity against planktonic and sessile growth of Staphylococcus aureus. NanoHA matrix was able to absorb both types of propolis and the obtained results revealed the antibacterial effectiveness of the novel materials expressed as the reduction of bacterial growth and biofilm formation ability. Additionally, cell culture tests showed the growth of fibroblasts with high metabolic activity and without membrane damage. Therefore, these nanoHA-based surfaces containing natural products deriving from bees may be a promising bioactive biomaterial to be further studied with the aim of application to orthopaedic or dental devices.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1088/1748-6041/10/2/025004pt_PT
dc.identifier.issn1748-6041
dc.identifier.urihttp://hdl.handle.net/10284/8006
dc.language.isoengpt_PT
dc.publisherIOP Publishingpt_PT
dc.relation.publisherversionhttps://iopscience.iop.org/article/10.1088/1748-6041/10/2/025004pt_PT
dc.subject3T3-L1 Cellspt_PT
dc.subjectAnimalspt_PT
dc.subjectAnti-infective agentspt_PT
dc.subjectBiocompatible materialspt_PT
dc.subjectBiofilmspt_PT
dc.subjectDurapatitept_PT
dc.subjectFibroblastspt_PT
dc.subjectHumanspt_PT
dc.subjectIn vitro techniquespt_PT
dc.subjectMaterials testingpt_PT
dc.subjectMicept_PT
dc.subjectNanostructurespt_PT
dc.subjectPropolispt_PT
dc.subjectProsthesis-related infectionspt_PT
dc.subjectStaphylococcus aureuspt_PT
dc.titleIn vitroantimicrobial activity and biocompatibility of propolis containing nanohydroxyapatitept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.startPage025004pt_PT
oaire.citation.titleBiomedical Materialspt_PT
oaire.citation.volume10pt_PT
person.familyNameGrenho
person.familyNameFerraz
person.givenNameLiliana
person.givenNameMaria Pia
person.identifierR-000-M1P
person.identifier.ciencia-idB41C-D747-BDBF
person.identifier.ciencia-id7F16-B2FB-9AD4
person.identifier.orcid0000-0001-9476-2839
person.identifier.orcid0000-0002-0274-106X
person.identifier.ridI-4540-2015
person.identifier.ridM-6316-2013
person.identifier.scopus-author-id55159751400
person.identifier.scopus-author-id7102012951
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb26a2a2c-0484-4214-97b3-b7ea69b58419
relation.isAuthorOfPublication7ba2ac59-40af-4ba1-b13e-4447f1686208
relation.isAuthorOfPublication.latestForDiscovery7ba2ac59-40af-4ba1-b13e-4447f1686208

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